FII · [(3,7,11-trimethyl-dodeca-2,6,10-trienyloxycarbamoyl)-methyl]-phosphonic acid

Binding sites

FII in 7 structures; the first of them:

• 1D8D · Co-crystal structure of rat protein farnesyltransferase complexed with a K-RAS4B peptide… · FII B1000 · binds LYS164, TYR166, TYR200, HIS201, TRP102, ARG202, TYR205, CYS206 and 12 more
• 1D8E · Zinc-depleted FTase complexed with K-RAS4B peptide substrate and FPP analog. · FII B3003 · binds LYS164, TYR166, TYR200, HIS201, TRP102, TYR154, ARG202, TYR205 and 11 more
• 1JCS · Crystal structure of rat protein farnesyltransferase complexed with the peptide substrate… · FII B1002 · binds LYS164, TYR166, TYR200, HIS201, TRP102, TYR154, ARG202, TYR205 and 12 more
• 1TN6 · Protein Farnesyltransferase Complexed with a Rap2a Peptide Substrate and a FPP Analog at… · FII B1 · binds LYS164, TYR166, TYR200, HIS201, TRP602, TYR654, ARG702, TYR705 and 13 more
• 1TN7 · Protein Farnesyltransferase Complexed with a TC21 Peptide Substrate and a FPP Analog at… · FII B1 · binds LYS164, TYR166, TYR200, HIS201, TRP602, ARG702, TYR705, CYS706 and 13 more
• 1TN8 · Protein Farnesyltransferase Complexed with a H-Ras Peptide Substrate and a FPP Analog at… · FII B1 · binds LYS164, TYR166, TYR200, HIS201, TRP602, TYR654, ARG702, TYR705 and 12 more
• 8T70 · Cryptococcus neoformans protein farnesyltransferase in complex with FPTII and TKCMIIM… · FII B605 · binds TYR109, TYR145, HIS146, TRP90, LEU141, ARG197, TYR200, CYS201 and 10 more

Residues it binds most

TYR 7, ARG 7, HIS 7, TRP 7, LYS 7, CYS 7, GLY 7, ILE 5, VAL 5, LEU 2 (residue and the binding sites it lines).

Found with

• ZN · Zinc ion
• ACY · Acetic acid
• ACT · Acetate ion
• 3FX · (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid
• BT6 · benzenethiol
• FRU · beta-D-fructofuranose
• GLC · alpha-D-glucopyranose
• EDO · 1,2-ethanediol