UniProt I3VE75
2-hydroxyisobutyryl-CoA synthetase (I3VE75)
2-hydroxyisobutyryl-CoA synthetase (UniProt I3VE75), EC 6.2.1.-: 10 experimental structures on GenesisL1, 8 ligands bound, 7 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- I3VE75
- Protein
- 2-hydroxyisobutyryl-CoA synthetase
- EC
- 6.2.1.-
- Experimental structures
- 10
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 7 · 1 record with a druggable one
Structures
10 records of I3VE75 in the MolNFT archive: 10 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6HDW | Crystal structure of 2-Hydroxyisobutyryl-CoA Ligase (HCL) in the postadenylation state in complex… | x-ray diffraction | A | 8LE, SO4 | — |
| 6HDW | Crystal structure of 2-hydroxyisobutyryl-CoA ligase (hcl) in the postadenylation state in complex… | x-ray diffraction | A | 8LE, SO4 | — |
| 6HDX | Crystal structure of 2-Hydroxyisobutyryl-CoA Ligase (HCL) in the postadenylation state in complex… | x-ray diffraction | A | 8LH, HIU | — |
| 6HDX | Crystal structure of 2-hydroxyisobutyryl-CoA ligase (hcl) in the postadenylation state in complex… | x-ray diffraction | A | 8LH, HIU | — |
| 6HDY | Crystal structure of 2-Hydroxyisobutyryl-CoA Ligase (HCL) in the postadenylation state in complex… | x-ray diffraction | A | 3HL, 8LQ, SO4 | — |
| 6HDY | Crystal structure of 2-hydroxyisobutyryl-CoA ligase (hcl) in the postadenylation state in complex… | x-ray diffraction | A | 3HL, 8LQ, SO4 | — |
| 6HE0 | Crystal structure of 2-Hydroxyisobutyryl-CoA Ligase (HCL) in complex with 2-HIB-AMP and CoA in the… | x-ray diffraction | A | 8LE, AMP, COA | — |
| 6HE0 | Crystal structure of 2-hydroxyisobutyryl-CoA ligase (hcl) in complex with 2-hib-AMP and CoA in the… | x-ray diffraction | A | 8LE, AMP, COA | — |
| 6HE2 | Crystal structure of an open conformation of 2-Hydroxyisobutyryl-CoA Ligase (HCL) in complex with… | x-ray diffraction | A, B | AMP, 8LE, COA | 7 (best 0.66) |
| 6HE2 | Crystal structure of an open conformation of 2-hydroxyisobutyryl-CoA ligase (hcl) in complex with… | x-ray diffraction | A, B | AMP, 8LE, COA | — |
Ligands
- 8LE · [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] 2-methyl-2-oxidanyl-propanoate · in 6 records
- AMP · Adenosine monophosphate · in 4 records
- COA · Coenzyme A · in 4 records
- SO4 · Sulfate ion · in 4 records
- 3HL · (3S)-3-hydroxybutanoic acid · in 2 records
- 8LH · [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] (2~{R})-2-methyl-3-oxidanyl-propanoate · in 2 records
- 8LQ · [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] (3~{S})-3-oxidanylbutanoate · in 2 records
- HIU · (2R)-3-hydroxy-2-methylpropanoic acid · in 2 records
Elsewhere
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