UniProt I3L466
Histone acetyltransferase (I3L466)
Histone acetyltransferase (UniProt I3L466), EC 2.3.1.48: 6 experimental structures on GenesisL1, 7 ligands bound, 9 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- I3L466
- Protein
- Histone acetyltransferase
- EC
- 2.3.1.48
- Experimental structures
- 6
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 9 · 2 records with a druggable one
Structures
6 records of I3L466 in the MolNFT archive: 6 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6LQX | Crystal structure of the CBP bromodomain in complex with small molecule LC-CPin7 | x-ray diffraction | B, A, D, C | EOO, NA | — |
| 6LQX | Crystal structure of the cbp bromodomain in complex with small molecule lc-CPIN7 | x-ray diffraction | B, A, D, C | EOO, NA | — |
| 7KPY | Crystal structure of CBP bromodomain liganded with UMB298 (compound 23) | x-ray diffraction | A, B | WU1 | 4 (best 0.46) |
| 7KPY | Crystal structure of cbp bromodomain liganded with UMB298 (compound 23) | x-ray diffraction | A, B | WU1 | — |
| 7UGL | Bromodomain of CBP liganded with BMS-536924 and SGC-CBP30 | x-ray diffraction | A, B | N6I, 2LO | 3 (best 0.65) |
| 8FVS | Bromodomain of CBP liganded with CCS1477int | x-ray diffraction | A, B | YBE, MG | 2 (best 0.65) |
Ligands
- EOO · (1~{S},6~{R})-6-[(1-methoxycarbonyl-3,4-dihydro-2~{H}-quinolin-6-yl)carbamoyl]cyclohex-3-ene-1-carboxylic acid · in 2 records
- NA · Sodium ion · in 2 records
- WU1 · 2-[2-(3-chloranyl-4-methoxy-phenyl)ethyl]-~{N}-cyclohexyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)imidazo[1, 2-a]pyridin-3-amine · in 2 records
- 2LO · 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole · in 1 record
- MG · Magnesium ion · in 1 record
- N6I · (3M)-4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one · in 1 record
- YBE · tert-butyl [(1R,4s)-4-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(2S)-6-oxopiperidin-2-yl]-1H-benzimidazol-1-yl}cyclohexyl]carbamate · in 1 record
Elsewhere
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