UniProt G2IQS8
5,10-methylenetetrahydrofolate reductase (G2IQS8)
5,10-methylenetetrahydrofolate reductase (UniProt G2IQS8), EC 1.5.1.20: 2 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 13 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- G2IQS8
- Protein
- 5,10-methylenetetrahydrofolate reductase
- EC
- 1.5.1.20
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 13 · 2 records with a druggable one
Structures
3 records of G2IQS8 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7XG9 | Crystal structural of methylenetetrahydrofolate reductase from Sphingobium sp. SYK-6 | x-ray diffraction | A, B | FAD | 8 (best 0.75) |
| 7XLF | Crystal structure of CH3-THF complex of methylenetetrahydrofolate reductase from Sphingobium sp.… | x-ray diffraction | A, B | FAD, C2F | 5 (best 0.74) |
| G2IQS8 | AlphaFold monomer V2.0 prediction for 5,10-methylenetetrahydrofolate reductase (G2IQS8) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7XLF chain A against the predicted model G2IQS8: TM-score 0.97, RMSD 1.35 Å
- 7XLF chain B against the predicted model G2IQS8: TM-score 0.96, RMSD 1.36 Å
- 7XG9 chain B against the predicted model G2IQS8: TM-score 0.96, RMSD 1.22 Å
- 7XG9 chain A against the predicted model G2IQS8: TM-score 0.95, RMSD 1.54 Å
Elsewhere
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