UniProt E9QLC0
5-hydroxytryptamine receptor 3A (E9QLC0)
5-hydroxytryptamine receptor 3A (UniProt E9QLC0): 17 experimental structures on GenesisL1, 7 ligands bound, 180 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- E9QLC0
- Protein
- 5-hydroxytryptamine receptor 3A
- Experimental structures
- 17
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 180 · 9 records with a druggable one
Structures
17 records of E9QLC0 in the MolNFT archive: 17 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6BE1 | Cryo-EM structure of serotonin receptor | electron microscopy | A, B, C, D, E | NAG, PX4, CL | 20 (best 0.90) |
| 6BE1 | Cryo-EM structure of serotonin receptor | electron microscopy | A, B, C, D, E | NAG, PX4 | — |
| 6DG7 | Full-length 5-HT3A receptor in a serotonin-bound conformation- State 1 | electron microscopy | A, B, C, D, E | NAG, SRO | 20 (best 0.90) |
| 6DG7 | Full-length 5-HT3A receptor in a serotonin-bound conformation- state 1 | electron microscopy | A, B, C, D, E | NAG, SRO | — |
| 6DG8 | Full-length 5-HT3A receptor in a serotonin-bound conformation- State 2 | electron microscopy | A, B, C, D, E | NAG, SRO | 20 (best 0.87) |
| 6DG8 | Full-length 5-HT3A receptor in a serotonin-bound conformation- state 2 | electron microscopy | A, B, C, D, E | NAG, SRO | — |
| 6HIN | Mouse serotonin 5-HT3 receptor, serotonin-bound, F conformation | electron microscopy | A, B, C, D, E | NAG, SRO | — |
| 6HIO | Mouse serotonin 5-HT3 receptor, serotonin-bound, I1 conformation | electron microscopy | A, E, B, C, D | NAG, SRO | — |
| 6HIQ | Mouse serotonin 5-HT3 receptor, serotonin-bound, I2 conformation | electron microscopy | A, E, B, C, D | NAG, SRO | — |
| 6NP0 | Cryo-EM structure of 5HT3A receptor in presence of granisetron | electron microscopy | A, B, C, D, E | NAG, CWB | — |
| 6NP0 | Cryo-EM structure of 5HT3A receptor in presence of granisetron | electron microscopy | A, B, C, D, E | NAG, CWB | — |
| 8FRW | Full-length mouse 5-HT3A receptor in complex with ALB148471, pre-activated | electron microscopy | A, B, C, D, E | NAG, Y7H | 20 (best 0.85) |
| 8FRX | Full-length mouse 5-HT3A receptor in complex with SMP100, pre-activated | electron microscopy | A, B, C, D, E | Y82, NAG | 20 (best 0.80) |
| 8FRZ | Full-length mouse 5-HT3A receptor in complex with serotonin, pre-activated | electron microscopy | A, B, C, D, E | SRO, NAG | 20 (best 0.84) |
| 8FSB | Full-length mouse 5-HT3A receptor in complex with serotonin, open-like | electron microscopy | A, B, C, D, E | NAG, SRO | 20 (best 0.85) |
| 8FSP | Full-length mouse 5-HT3A receptor in complex with SMP100, open-like | electron microscopy | A, B, C, D, E | NAG, Y82 | 20 (best 0.87) |
| 8FSZ | Full-length mouse 5-HT3A receptor in complex with ALB148471, open-like | electron microscopy | A, B, C, D, E | Y7H, NAG | 20 (best 0.85) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 17 records
- SRO · Serotonin · in 9 records
- CWB · 1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide · in 2 records
- PX4 · 1,2-dimyristoyl-sn-glycero-3-phosphocholine · in 2 records
- Y7H · 5-[(1R,3S,5R)-1-azabicyclo[3.2.2]nonan-3-yl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indazol-6-one · in 2 records
- Y82 · 5-[(1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indazol-6-one · in 2 records
- CL · Chloride ion · in 1 record
Elsewhere
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