MolNFT v1 · #151273 · protein
Mouse serotonin 5-HT3 receptor, serotonin-bound, I2 conformation
6HIQ · 5-hydroxytryptamine receptor 3A: “Mouse serotonin 5-HT3 receptor, serotonin-bound, I2 conformation”. Electron microscopy, 2 ligands (SRO, NAG), 20 pockets (best druggability 0.87). MolNFT v1 #151273 on GenesisL1: 3D structure…
- PDB
- 6HIQ
- Type
- protein
- Length
- 1,925 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5-hydroxytryptamine receptor 3A
- UniProt
- E9QLC0
- Ligands
- SRO, NAG
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 1 distinct chain · 39% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E, B, C, D | 5-hydroxytryptamine receptor 3A | protein | 385 | 39% helix, 25% strand | E9QLC0 |
Ligands and binding sites
- SRO · Serotonin · ligand · 5 copies · chains A, E, D, B, C
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 25 copies · chains A, E, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 790 | 0.87 | 0.90 | 106 | empty |
| 2 | 798 | 0.86 | 0.88 | 103 | empty |
| 3 | 515 | 0.84 | 0.90 | 79 | empty |
| 4 | 358 | 0.81 | 0.90 | 48 | empty |
| 5 | 739 | 0.80 | 0.84 | 72 | empty |
Interfaces
5 interfaces between chains.
- A–E · 3397 Ų buried · 26 hydrogen bonds · protein-protein
- A–B · 3333 Ų buried · 24 hydrogen bonds · protein-protein
- B–C · 3311 Ų buried · 24 hydrogen bonds · protein-protein
- C–D · 3288 Ų buried · 20 hydrogen bonds · protein-protein
- E–D · 3225 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 15 glycan, 5 disulfide (N-glycosylation, disulfide).
Compared structures
- 6HIQ · Mouse serotonin 5-HT3 receptor, serotonin-bound, I2 conformation · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E9QLC0
- Elsewhere: RCSB PDB 6HIQ · PDBe 6HIQ · UniProt E9QLC0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.