UniProt C3TR70
Dihydrofolate reductase (C3TR70)
Dihydrofolate reductase (UniProt C3TR70), EC 1.5.1.3: 14 experimental structures on GenesisL1, 8 ligands bound, 3 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- C3TR70
- Protein
- Dihydrofolate reductase
- EC
- 1.5.1.3
- Experimental structures
- 14
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 3 · 2 records with a druggable one
Structures
14 records of C3TR70 in the MolNFT archive: 14 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4P66 | Electrostatics of Active Site Microenvironments of E. coli DHFR | x-ray diffraction | A | — | — |
| 4P66 | Electrostatics of active site microenvironments of E. COLI DHFR | x-ray diffraction | A | — | — |
| 4P68 | Electrostatics of Active Site Microenvironments for E. coli DHFR | x-ray diffraction | A | — | — |
| 4P68 | Electrostatics of active site microenvironments for E. COLI DHFR | x-ray diffraction | A | — | — |
| 5E8Q | Crystal structure of DHFR in 20% Isopropanol | x-ray diffraction | B, A | CA, CL | — |
| 5E8Q | Crystal structure of DHFR in 20% isopropanol | x-ray diffraction | B, A | — | — |
| 5EAJ | Crystal structure of DHFR in 0% Isopropanol | x-ray diffraction | B, A | CA, CL | — |
| 5EAJ | Crystal structure of DHFR in 0% isopropanol | x-ray diffraction | B, A | — | — |
| 5UJX | Crystal structure of DHFR in 20% Isopropanol | x-ray diffraction | B, A | CA, CL | — |
| 5UJX | Crystal structure of DHFR in 20% isopropanol | x-ray diffraction | B, A | CA, CL | — |
| 7MQP | E. coli dihydrofolate reductase complexed with 4'-chloro-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)bu… | x-ray diffraction | A | ZM4, SO4 | 2 (best 0.59) |
| 7MQP | E. COLI dihydrofolate reductase complexed with 4'-chloro-3'-(4-(2,4… | x-ray diffraction | A | ZM4, SO4 | — |
| 7REB | E. COLI dihydrofolate reductase complexed with 5-(3-(7-(4… | x-ray diffraction | A | SO4, 560 | — |
| 8UW0 | Escherichia coli DHFR bound to NADP+ and folate, 17.2 MGy dose | x-ray diffraction | A | FOL, NAP, MN | 1 (best 0.69) |
Ligands
- CA · Calcium ion · in 4 records
- CL · Chloride ion · in 4 records
- SO4 · Sulfate ion · in 3 records
- ZM4 · 3'-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-4'-methyl[1,1'-biphenyl]-4-carboxamide · in 2 records
- 560 · 5-[(3R)-3-{7-[4-(aminomethyl)phenyl]-2H-1,3-benzodioxol-5-yl}but-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine · in 1 record
- FOL · Folic acid · in 1 record
- MN · Manganese (II) ion · in 1 record
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 1 record
Elsewhere
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