UniProt B7MLA1
CTP synthase (B7MLA1)
CTP synthase (UniProt B7MLA1), EC 6.3.4.2: 10 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 49 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- B7MLA1
- Protein
- CTP synthase
- EC
- 6.3.4.2
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 49 · 6 records with a druggable one
Structures
11 records of B7MLA1 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5U05 | Cryo-EM structure of the E. COLI CTP synthase tetramer | electron microscopy | A, B, C, D | — | — |
| 5U3C | CryoEM structure of the CTP synthase filament at 4.6 Angstrom resolution | electron microscopy | A, B, C, D | CTP, ADP | — |
| 5U3C | Cryoem structure of the CTP synthase filament at 4.6 ångström resolution | electron microscopy | A, B, C, D | CTP, ADP | — |
| 5U6R | E. coli CTP synthase CC mutant filament (product-bound) | electron microscopy | A, B, C, D | CTP, ADP | — |
| 5U6R | E. COLI CTP synthase cc mutant filament (product-bound) | electron microscopy | A, B, C, D | CTP, ADP | — |
| 8FV6 | E coli. CTP synthase in complex with dF-dCTP | x-ray diffraction | AAA, BBB | GTF, NA | 8 (best 0.74) |
| 8FV7 | E coli. CTP synthase in complex with dF-dCTP + ATP | x-ray diffraction | AAA, BBB | ATP, NA, GTF | 8 (best 0.75) |
| 8FV8 | E coli. CTP synthase in complex with dF-dCTP + ADP | x-ray diffraction | AAA, BBB | ADP, GTF, NA | 8 (best 0.73) |
| 8FVB | E coli. CTP synthase in complex with CTP | x-ray diffraction | AAA, BBB | CTP | 11 (best 0.70) |
| 8SBR | E coli. CTP synthase in complex with CTP (sodium malonate + 20 mM MgCl2) | x-ray diffraction | A, B | CTP | 8 (best 0.72) |
| B7MLA1 | AlphaFold monomer V2.0 prediction for CTP synthase (B7MLA1) | predicted | A | — | 6 (best 0.72) |
Ligands
Experiment against prediction
- 8FVB chain AAA against the predicted model B7MLA1: TM-score 0.97, RMSD 0.87 Å
- 8FV6 chain AAA against the predicted model B7MLA1: TM-score 0.97, RMSD 1.08 Å
- 8FVB chain BBB against the predicted model B7MLA1: TM-score 0.97, RMSD 0.90 Å
- 8SBR chain A against the predicted model B7MLA1: TM-score 0.97, RMSD 0.93 Å
- 8FV8 chain AAA against the predicted model B7MLA1: TM-score 0.97, RMSD 0.94 Å
- 5U3C chain A against the predicted model B7MLA1: TM-score 0.97, RMSD 0.98 Å
- 5U3C chain A against the predicted model B7MLA1: TM-score 0.97, RMSD 0.98 Å
- 5U6R chain A against the predicted model B7MLA1: TM-score 0.97, RMSD 0.98 Å
- 5U6R chain A against the predicted model B7MLA1: TM-score 0.97, RMSD 0.98 Å
- 8SBR chain B against the predicted model B7MLA1: TM-score 0.97, RMSD 0.93 Å
Elsewhere
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