UniProt B6YWB8
CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) (B6YWB8)
CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) (UniProt B6YWB8), EC 2.7.7.-, 3.1.-.-: 30 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 44 pockets. Binding sites…
- UniProt
- B6YWB8
- Protein
- CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype…
- EC
- 2.7.7.-, 3.1.-.-
- Experimental structures
- 30
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 44 · 4 records with a druggable one
Structures
31 records of B6YWB8 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4UW2 | Crystal structure of Csm1 in T.onnurineus | x-ray diffraction | A, B, C, D | — | — |
| 4UW2 | Crystal structure of CSM1 in T.ONNURINEUS | x-ray diffraction | A, B, C, D | — | — |
| 6IQW | Cryo-EM structure of Csm effector complex | electron microscopy | A | ATP | — |
| 6IQW | Cryo-EM structure of csm effector complex | electron microscopy | A | ATP | — |
| 6KBD | Fused to-MTBCSM1 with 2DATP | x-ray diffraction | A | DTP, MG | — |
| 6KC0 | fused To-MtbCsm1 with 2ATP | x-ray diffraction | A | ATP, MG | — |
| 6KC0 | Fused to-MTBCSM1 with 2ATP | x-ray diffraction | A | ATP, MG | — |
| 6MUA | Crystal structure of Csm1-Csm4 subcomplex in the type III-A CRISPR-Csm interference complex | x-ray diffraction | A | — | — |
| 6MUA | Crystal structure of CSM1-CSM4 subcomplex in the type III-a CRISPR-csm interference complex | x-ray diffraction | A | — | — |
| 6MUR | Cryo-EM structure of Csm-crRNA-target RNA ternary complex in type III-A CRISPR-Cas system | electron microscopy | A | ZN | — |
| 6MUR | Cryo-EM structure of csm-crrna-target RNA ternary complex in type III- a CRISPR-CAS system | electron microscopy | A | ZN | — |
| 6MUS | Cryo-EM structure of larger Csm-crRNA-target RNA ternary complex in type III-A CRISPR-Cas system | electron microscopy | A | ZN | — |
| 6MUS | Cryo-EM structure of larger csm-crrna-target RNA ternary complex in type III-a CRISPR-CAS system | electron microscopy | A | ZN | — |
| 6MUT | Cryo-EM structure of ternary csm-crrna-target RNA with anti-tag sequence complex in type III-a… | electron microscopy | A | ZN | — |
| 6MUU | Cryo-EM structure of csm-crrna binary complex in type III-a CRISPR-CAS system | electron microscopy | A | ZN | — |
| 6O73 | Crystal structure of apo CSM1-CSM4 cassette | x-ray diffraction | A | NI | — |
| 6O74 | Crystal structure of Csm1-Csm4 cassette in complex with AMPPNP | x-ray diffraction | A | ANP, MN | 12 (best 0.83) |
| 6O74 | Crystal structure of CSM1-CSM4 cassette in complex with amppnp | x-ray diffraction | A | ANP, MN | — |
| 6O75 | Crystal structure of CSM1-CSM4 cassette in complex with pppapa | x-ray diffraction | A | MN | — |
| 6O78 | Crystal structure of CSM1-CSM4 cassette in complex with pppapapa | x-ray diffraction | A | MN | — |
| 6O79 | Crystal structure of Csm1-Csm4 cassette in complex with cA3 | x-ray diffraction | A | — | 12 (best 0.82) |
| 6O79 | Crystal structure of CSM1-CSM4 cassette in complex with CA3 | x-ray diffraction | A | — | — |
| 6O7B | Crystal structure of CSM1-CSM4 cassette in complex with CA4 | x-ray diffraction | A | — | — |
| 6O7D | Crystal structure of Csm1-Csm4 cassette in complex with one ATP | x-ray diffraction | A | ATP, MN | 13 (best 0.85) |
| 6O7D | Crystal structure of CSM1-CSM4 cassette in complex with one ATP | x-ray diffraction | A | ATP, MN | — |
| 6O7E | Cryo-EM structure of Csm-crRNA-target RNA ternary complex in complex with AMPPNP in type III-A… | electron microscopy | A | ZN, ANP, MN | — |
| 6O7E | Cryo-EM structure of csm-crrna-target RNA ternary complex in complex with amppnp in type III-a… | electron microscopy | A | ZN, ANP, MN | — |
| 6O7H | Cryo-EM structure of csm-crrna-target RNA ternary complex in complex with CA4 in type III-a… | electron microscopy | A | ZN | — |
| 6O7I | Cryo-EM structure of Csm-crRNA-target RNA ternary bigger complex in complex with cA4 in type III-A… | electron microscopy | A | ZN | 7 (best 0.82) |
| 6O7I | Cryo-EM structure of csm-crrna-target RNA ternary bigger complex in complex with CA4 in type III-a… | electron microscopy | A | ZN | — |
| B6YWB8 | AlphaFold monomer V2.0 prediction for CRISPR system single-strand- specific deoxyribonuclease… | predicted | A | — | — |
Ligands
Experiment against prediction
- 6MUA chain A against the predicted model B6YWB8: TM-score 0.99, RMSD 1.07 Å
- 6MUA chain A against the predicted model B6YWB8: TM-score 0.99, RMSD 1.07 Å
- 6O79 chain A against the predicted model B6YWB8: TM-score 0.99, RMSD 1.07 Å
- 6O79 chain A against the predicted model B6YWB8: TM-score 0.99, RMSD 1.07 Å
- 6O74 chain A against the predicted model B6YWB8: TM-score 0.99, RMSD 1.09 Å
- 6O74 chain A against the predicted model B6YWB8: TM-score 0.99, RMSD 1.09 Å
- 6O7B chain A against the predicted model B6YWB8: TM-score 0.99, RMSD 1.09 Å
- 6O73 chain A against the predicted model B6YWB8: TM-score 0.99, RMSD 1.10 Å
- 6O7D chain A against the predicted model B6YWB8: TM-score 0.99, RMSD 1.10 Å
- 6O7D chain A against the predicted model B6YWB8: TM-score 0.99, RMSD 1.10 Å
Elsewhere
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