UniProt A8EVM5
Ion transport protein (A8EVM5)
Ion transport protein (UniProt A8EVM5): 79 experimental structures on GenesisL1, 24 ligands bound, 29 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A8EVM5
- Protein
- Ion transport protein
- Experimental structures
- 79
- Predicted models
- 0
- Ligands
- 24
- Pockets
- 29 · 3 records with a druggable one
Structures
79 records of A8EVM5 in the MolNFT archive: 79 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3RVY | Crystal structure of the NavAb voltage-gated sodium channel (Ile217Cys, 2.7 A) | x-ray diffraction | A, B | — | — |
| 3RVY | Crystal structure of the navab voltage-gated sodium channel (ILE217CYS, 2.7 a) | x-ray diffraction | A, B | — | — |
| 3RVZ | Crystal structure of the NavAb voltage-gated sodium channel (Ile217Cys, 2.8 A) | x-ray diffraction | A, B | — | — |
| 3RVZ | Crystal structure of the navab voltage-gated sodium channel (ILE217CYS, 2.8 a) | x-ray diffraction | A, B | — | — |
| 3RW0 | Crystal structure of the NavAb voltage-gated sodium channel (Met221Cys, 2.95 A) | x-ray diffraction | A, B | — | — |
| 3RW0 | Crystal structure of the navab voltage-gated sodium channel (MET221CYS, 2.95 a) | x-ray diffraction | A, B | — | — |
| 4EKW | Crystal structure of the NavAb voltage-gated sodium channel (wild-type, 3.2 A) | x-ray diffraction | A, B, C, D | — | — |
| 4EKW | Crystal structure of the navab voltage-gated sodium channel (wild- type, 3.2 a) | x-ray diffraction | A, B, C, D | — | — |
| 4MS2 | Structural basis of Ca2+ selectivity of a voltage-gated calcium channel | x-ray diffraction | A, B, C, D | — | — |
| 4MS2 | Structural basis of CA2+ selectivity of a voltage-gated calcium channel | x-ray diffraction | A, B, C, D | — | — |
| 4MTF | Structural Basis of Ca2+ Selectivity of a Voltage-gated Calcium Channel | x-ray diffraction | A, B, C, D | — | — |
| 4MTF | Structural basis of CA2+ selectivity of a voltage-gated calcium channel | x-ray diffraction | A, B, C, D | — | — |
| 4MTG | Structural Basis for Ca2+ Selectivity of a Voltage-gated Calcium Channel | x-ray diffraction | A, B, C, D | — | — |
| 4MTG | Structural basis for CA2+ selectivity of a voltage-gated calcium channel | x-ray diffraction | A, B, C, D | — | — |
| 4MTO | Structural Basis for Ca2+ Selectivity of a Voltage-gated Calcium Channel | x-ray diffraction | A, B, C, D | — | — |
| 4MTO | Structural basis for CA2+ selectivity of a voltage-gated calcium channel | x-ray diffraction | A, B, C, D | — | — |
| 4MVM | Structural Basis for Ca2+ Selectivity of a Voltage-gated Calcium Channel | x-ray diffraction | A, B, C, D | — | — |
| 4MVM | Structural basis for CA2+ selectivity of a voltage-gated calcium channel | x-ray diffraction | A, B, C, D | — | — |
| 4MVO | Structural Basis for Ca2+ Selectivity of a Voltage-gated Calcium Channel | x-ray diffraction | A, B, C, D | — | — |
| 4MVO | Structural basis for CA2+ selectivity of a voltage-gated calcium channel | x-ray diffraction | A, B, C, D | — | — |
| 4MVQ | Structural Basis for Ca2+ Selectivity of a Voltage-gated Calcium Channel | x-ray diffraction | A, B, C, D | — | — |
| 4MVQ | Structural basis for CA2+ selectivity of a voltage-gated calcium channel | x-ray diffraction | A, B, C, D | — | — |
| 4MVR | Structural Basis for Ca2+ Selectivity of a Voltage-gated Calcium Channel | x-ray diffraction | A, B, C, D | — | — |
| 4MVR | Structural basis for CA2+ selectivity of a voltage-gated calcium channel | x-ray diffraction | A, B, C, D | — | — |
| 4MVS | Structural Basis for Ca2+ Selectivity of a Voltage-gated Calcium Channel | x-ray diffraction | A, B, C, D | — | — |
| 4MVS | Structural basis for CA2+ selectivity of a voltage-gated calcium channel | x-ray diffraction | A, B, C, D | — | — |
| 4MVU | Structural Basis for Ca2+ Selectivity of a Voltage-gated Calcium Channel | x-ray diffraction | A, B, C, D | — | — |
| 4MVU | Structural basis for CA2+ selectivity of a voltage-gated calcium channel | x-ray diffraction | A, B, C, D | — | — |
| 4MVZ | Structural Basis for Ca2+ Selectivity of a Voltage-gated Calcium Channel | x-ray diffraction | A, B, C, D | — | — |
| 4MVZ | Structural basis for CA2+ selectivity of a voltage-gated calcium channel | x-ray diffraction | A, B, C, D | — | — |
| 4MW3 | Structural Basis for Ca2+ Selectivity of a Voltage-gated Calcium Channel | x-ray diffraction | A, B, C, D | — | — |
| 4MW3 | Structural basis for CA2+ selectivity of a voltage-gated calcium channel | x-ray diffraction | A, B, C, D | — | — |
| 4MW8 | Structural Basis for Ca2+ Selectivity of a Voltage-gated Calcium Channel | x-ray diffraction | A, B, C, D | — | — |
| 4MW8 | Structural basis for CA2+ selectivity of a voltage-gated calcium channel | x-ray diffraction | A, B, C, D | — | — |
| 5EK0 | Human NAV1.7-VSD4-navab in complex with gx-936. | x-ray diffraction | A, B, C, D | — | — |
| 5KLB | Crystal structure of the CavAb voltage-gated calcium channel(wild-type, 2.7A) | x-ray diffraction | A, B, C, D | MC3, CA, CPS | — |
| 5KLB | Crystal structure of the cavab voltage-gated calcium CHANNEL(WILD- type, 2.7A) | x-ray diffraction | A, B, C, D | MC3, CA, CPS | — |
| 5KLG | Structure of CAVAB(W195Y) in complex with br-dihydropyridine derivative uk-59811 | x-ray diffraction | A, B, C, D | CA, MC3, 6UC | — |
| 5KLS | Structure of cavab in complex with br-dihydropyridine derivative uk- 59811 | x-ray diffraction | A, B, C, D | MC3, CA, 6UC | — |
| 5KMD | Structure of cavab in complex with amlodipine | x-ray diffraction | A, B, C, D | MC3, CA, 6UB | — |
| 5KMF | Structure of cavab in complex with nimodipine | x-ray diffraction | A, B, C, D | 6U9, MC3, CA | — |
| 5KMH | Structure of CavAb in complex with Br-verapamil | x-ray diffraction | A, B, C, D | CA, MC3, PX6, 6U8 | — |
| 5KMH | Structure of cavab in complex with br-verapamil | x-ray diffraction | A, B, C, D | CA, MC3, PX6, 6U8 | — |
| 5VB2 | Crystal structure of the navab voltage-gated sodium channel in a closed conformation | x-ray diffraction | A, B, C, D | CPS, PX4, PO4, CL | — |
| 5VB8 | Crystal structure of the NavAb voltage-gated sodium channel in an open state | x-ray diffraction | A | PX4, SO4 | — |
| 5VB8 | Crystal structure of the navab voltage-gated sodium channel in an open state | x-ray diffraction | A | PX4, SO4 | — |
| 6C1E | Navab normopp mutant | x-ray diffraction | A, B | PX4, BNC, UHH | — |
| 6C1K | Hypopp mutant with LIGAND1 | x-ray diffraction | A, B | GAI, PX4, NA, SO4 | — |
| 6C1M | Navab normopp mutant | x-ray diffraction | A, B | PX4, 1N7, MGX, NA, SO4 | — |
| 6C1P | Hypopp mutant | x-ray diffraction | A, B, C, D | PX4, 1N7 | — |
| 6JUH | structure of CavAb in complex with efonidipine | x-ray diffraction | A, B, C, D | MC3, PX4, G3P, CA, C9X | — |
| 6JUH | Structure of cavab in complex with efonidipine | x-ray diffraction | A, B, C, D | MC3, PX4, G3P, CA, C9X | — |
| 6KE5 | Structure of CavAb in complex with Diltiazem and Amlodipine | x-ray diffraction | A, B, C, D | LPC, CA, G3P, 6UB, D6C | — |
| 6KE5 | Structure of cavab in complex with diltiazem and amlodipine | x-ray diffraction | A, B, C, D | LPC, CA, G3P, 6UB, D6C | — |
| 6KEB | Structure basis for Diltiazem block of a voltage-gated calcium channel | x-ray diffraction | A, B, C, D | PX4, CA, D6C | — |
| 6KEB | Structure basis for diltiazem block of a voltage-gated calcium channel | x-ray diffraction | A, B, C, D | PX4, CA, D6C | — |
| 6MVV | Navab voltage-gated sodium channel, I217C/F203A | x-ray diffraction | A, B, C, D | PX4, PO4 | — |
| 6MVW | Navab voltage-gated sodium channel, I217C/F203W | x-ray diffraction | A, B, C, D | PX4, PO4 | — |
| 6MVX | Navab voltage-gated sodium channel, I217C, in complex with class 1C anti-arrhythmic flecainide | x-ray diffraction | A, B, C, D | PO4, K4D | — |
| 6MVY | Navab voltage-gated sodium channel, residues 1-226, crystallized in the presence of class 1B… | x-ray diffraction | A, B | PX4, SO4 | — |
19 records more on the page itself.
Ligands
- PX4 · 1,2-dimyristoyl-sn-glycero-3-phosphocholine · in 28 records
- CPS · 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate · in 15 records
- CA · Calcium ion · in 14 records
- MC3 · 1,2-dimyristoyl-rac-glycero-3-phosphocholine · in 10 records
- SO4 · Sulfate ion · in 10 records
- 1N7 · Chapso · in 4 records
- D6C · [(2~{S},3~{R})-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxidanylidene-2,3-dihydro-1,5-benzothiazepin-3-yl] ethanoate · in 4 records
- G3P · Sn-glycerol-3-phosphate · in 4 records
- PO4 · Phosphate ion · in 4 records
- 6UB · amlodipine · in 3 records
- NA · Sodium ion · in 3 records
- 6U8 · (2~{R})-2-(2-bromophenyl)-5-[2-(3,4-dimethoxyphenyl) ethyl-methyl-amino]-2-propan-2-yl-pentanenitrile · in 2 records
- 6UC · O3-ethyl O5-methyl (4R)-4-(2-bromophenyl)-2-[2-(dimethylamino)ethoxymethyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate · in 2 records
- C9X · 2-[phenyl-(phenylmethyl)amino]ethyl (4~{R})-5-(5,5-dimethyl-2-oxidanylidene-1,3,2$l^{5}-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate · in 2 records
- LPC · [1-myristoyl-glycerol-3-yl]phosphonylcholine · in 2 records
- PX6 · 1,2-dipalmitoyl-sn-glycero-3-phosphate · in 2 records
- 6U9 · Nimodipine · in 1 record
- BGC · beta-D-glucopyranose · in 1 record
- BNC · 5-beta-24-nor-cholane-3(alpha),7(alpha),12(alpha)-triol · in 1 record
- CL · Chloride ion · in 1 record
- GAI · Guanidine · in 1 record
- K4D · Flecainide · in 1 record
- MGX · 1-methylguanidine · in 1 record
- UHH · (3alpha,5alpha,7alpha,8alpha,12alpha,14beta,17alpha)-3, 7,12-trihydroxychol-1-en-24-amide · in 1 record
Experiment against prediction
- 7K48 chain A against the predicted model Q15858: TM-score 0.87, RMSD 2.29 Å
- 5EK0 chain B against the predicted model Q15858: TM-score 0.86, RMSD 2.69 Å
- 5EK0 chain A against the predicted model Q15858: TM-score 0.86, RMSD 2.67 Å
- 6N4R chain B against the predicted model Q15858: TM-score 0.85, RMSD 2.42 Å
- 5EK0 chain C against the predicted model Q15858: TM-score 0.82, RMSD 2.61 Å
- 6N4Q chain B against the predicted model Q15858: TM-score 0.78, RMSD 2.77 Å
- 6N4R chain C against the predicted model Q15858: TM-score 0.77, RMSD 3.17 Å
- 6N4Q chain A against the predicted model Q15858: TM-score 0.76, RMSD 2.43 Å
Elsewhere
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