UniProt A4GRC7
Dihydrofolate reductase (A4GRC7)
Dihydrofolate reductase (UniProt A4GRC7), EC 1.5.1.3: 6 experimental structures on GenesisL1, 6 ligands bound, 9 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A4GRC7
- Protein
- Dihydrofolate reductase
- EC
- 1.5.1.3
- Experimental structures
- 6
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 9 · 1 record with a druggable one
Structures
6 records of A4GRC7 in the MolNFT archive: 6 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ECC | Klebsiella pneumoniae DfrA1 complexed with NADPH and… | x-ray diffraction | A, B | NAP, 6DR, CA | — |
| 5ECC | Klebsiella pneumoniae DFRA1 complexed with NADPH and 6-ethyl-5-(3-(2… | x-ray diffraction | A, B | — | — |
| 5ECX | Klebsiella pneumoniae DfrA1 complexed with NADPH and… | x-ray diffraction | A, B | NAP, 5N1, GLV | — |
| 5ECX | Klebsiella pneumoniae DFRA1 complexed with NADPH and 6-ethyl-5-(3-(6… | x-ray diffraction | A, B | — | — |
| 7MYL | Crystal structure of DfrA1 dihydrofolate reductase in complex with TRIMETHOPRIM | x-ray diffraction | A, B, C, D, E, F | TOP | 9 (best 0.79) |
| 7MYL | Crystal structure of DFRA1 dihydrofolate reductase in complex with trimethoprim | x-ray diffraction | A, B, C, D, E, F | TOP | — |
Ligands
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 2 records
- TOP · Trimethoprim · in 2 records
- 5N1 · 6-ethyl-5-[(3~{S})-3-(6-pyridin-4-yl-1,3-benzodioxol-4-yl)but-1-ynyl]pyrimidine-2,4-diamine · in 1 record
- 6DR · 6-ethyl-5-{3-[2-methoxy-5-(pyridin-4-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine · in 1 record
- CA · Calcium ion · in 1 record
- GLV · Glyoxylic acid · in 1 record
Elsewhere
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