UniProt A0A8V8TRG9
Metabotropic glutamate receptor 3,Serine/threonine-protein kinase mTOR (A0A8V8TRG9)
Metabotropic glutamate receptor 3,Serine/threonine-protein kinase mTOR (UniProt A0A8V8TRG9), EC 2.7.11.1: 10 experimental structures on GenesisL1, 4 ligands bound, 78 pockets. Binding sites, pockets, druggability and 3D…
- UniProt
- A0A8V8TRG9
- Protein
- Metabotropic glutamate receptor 3,Serine/threonine-protein kinase mTOR
- EC
- 2.7.11.1
- Experimental structures
- 10
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 78 · 10 records with a druggable one
Structures
10 records of A0A8V8TRG9 in the MolNFT archive: 10 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8JCU | Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode I) | electron microscopy | 3 | NAG, Z99 | 6 (best 0.83) |
| 8JCV | Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode II) | electron microscopy | 3 | NAG, Z99 | 10 (best 0.82) |
| 8JCW | Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 and NAM563 (dimerization mode… | electron microscopy | 3 | CLR, NAG, Z99 | 5 (best 0.84) |
| 8JCX | Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 and NAM563 (dimerization mode… | electron microscopy | 3 | NAG, Z99 | 7 (best 0.82) |
| 8JCY | Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495, NAM563, and LY2389575… | electron microscopy | 3 | CLR, NAG, Z99 | 6 (best 0.83) |
| 8JCZ | Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495, NAM563, and LY2389575… | electron microscopy | 3 | NAG, Z99 | 6 (best 0.86) |
| 8JD0 | Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of NAM563 | electron microscopy | 3 | CLR, GLU, NAG | 9 (best 0.77) |
| 8JD1 | Cryo-EM structure of mGlu2-mGlu3 heterodimer in Rco state | electron microscopy | 3 | GLU, CLR | 8 (best 0.85) |
| 8JD2 | Cryo-EM structure of G protein-free mGlu2-mGlu3 heterodimer in Acc state | electron microscopy | 3 | GLU, NAG | 10 (best 0.80) |
| 8JD4 | Cryo-EM structure of G protein-free mGlu2-mGlu4 heterodimer in Acc state | electron microscopy | 4 | GLU, NAG | 11 (best 0.81) |
Ligands
Experiment against prediction
- 8JD2 chain 3 against the predicted model Q14832: TM-score 0.94, RMSD 2.37 Å
- 8JD4 chain 4 against the predicted model Q14833: TM-score 0.92, RMSD 2.90 Å
- 8JCX chain 3 against the predicted model Q14832: TM-score 0.82, RMSD 4.68 Å
- 8JCV chain 3 against the predicted model Q14832: TM-score 0.81, RMSD 4.69 Å
- 8JD0 chain 3 against the predicted model Q14832: TM-score 0.80, RMSD 5.15 Å
- 8JD1 chain 3 against the predicted model Q14832: TM-score 0.79, RMSD 5.11 Å
- 8JCY chain 3 against the predicted model Q14832: TM-score 0.71, RMSD 6.36 Å
- 8JCW chain 3 against the predicted model Q14832: TM-score 0.70, RMSD 6.17 Å
- 8JCU chain 3 against the predicted model Q14832: TM-score 0.70, RMSD 6.32 Å
- 8JCZ chain 3 against the predicted model Q14832: TM-score 0.70, RMSD 5.77 Å
Elsewhere
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