UniProt A0A1G4H5I1

Serine hydroxymethyltransferase (A0A1G4H5I1)

Serine hydroxymethyltransferase (UniProt A0A1G4H5I1), EC 2.1.2.1: 28 experimental structures on GenesisL1, 16 ligands bound, 134 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt: A0A1G4H5I1
Protein: Serine hydroxymethyltransferase
EC: 2.1.2.1
Experimental structures: 28
Predicted models: 0
Ligands: 16
Pockets: 134 · 11 records with a druggable one

Structures

28 records of A0A1G4H5I1 in the MolNFT archive: 28 experimental, 0 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
5XMP	Plasmodium vivax SHMT(C346A) bound with PLP-glycine and MF057	x-ray diffraction	A, B, C	PLG, 8A3, CL	11 (best 0.81)
5XMP	Plasmodium vivax SHMT(C346A) bound with plp-glycine and MF057	x-ray diffraction	A, B, C	8A3, CL	—
5XMQ	Plasmodium vivax SHMT(C346A) bound with PLP-glycine and MF011	x-ray diffraction	A, B, C	PLG, 8A6, CL	13 (best 0.76)
5XMQ	Plasmodium vivax SHMT(C346A) bound with plp-glycine and MF011	x-ray diffraction	A, B, C	8A6, CL	—
5XMR	Plasmodium vivax SHMT(C346A) bound with PLP-glycine and GS395	x-ray diffraction	A, B, C	8AO, CL	—
5XMR	Plasmodium vivax SHMT(C346A) bound with plp-glycine and GS395	x-ray diffraction	A, B, C	8AO, CL	—
5XMS	Plasmodium vivax SHMT bound with PLP-glycine and GS498	x-ray diffraction	A, B, C	PLG, 8B3, CL	12 (best 0.76)
5XMS	Plasmodium vivax shmt bound with plp-glycine and GS498	x-ray diffraction	A, B, C	8B3, CL	—
5XMT	Plasmodium vivax SHMT bound with PLP-glycine and GS380	x-ray diffraction	A, B, C	PLG, 8B0, CL	12 (best 0.76)
5XMT	Plasmodium vivax shmt bound with plp-glycine and GS380	x-ray diffraction	A, B, C	8B0, CL	—
5XMU	Plasmodium vivax SHMT bound with PLP-glycine and GS363	x-ray diffraction	A, B, C	PLG, 8A0, CL	12 (best 0.76)
5XMU	Plasmodium vivax shmt bound with plp-glycine and GS363	x-ray diffraction	A, B, C	8A0, CL	—
5XMV	Plasmodium vivax SHMT bound with PLP-glycine and GS362	x-ray diffraction	A, B, C	PLG, 8AU, CL	11 (best 0.76)
5XMV	Plasmodium vivax shmt bound with plp-glycine and GS362	x-ray diffraction	A, B, C	8AU, CL	—
5YFY	Plasmodium vivax SHMT bound with PLP-glycine and GS625	x-ray diffraction	A, B, C	PLG, 8UL, CL	12 (best 0.77)
5YFY	Plasmodium vivax shmt bound with plp-glycine and GS625	x-ray diffraction	A, B, C	8UL, CL	—
5YFZ	Plasmodium vivax SHMT bound with PLP-glycine and S-GS626	x-ray diffraction	A, B, C	8UO, CL	—
5YFZ	Plasmodium vivax shmt bound with plp-glycine and S-GS626	x-ray diffraction	A, B, C	8UO, CL	—
5YG0	Plasmodium vivax SHMT bound with PLP-glycine and GS657	x-ray diffraction	A, B, C	PLG, 8UR, CL	13 (best 0.81)
5YG0	Plasmodium vivax shmt bound with plp-glycine and GS657	x-ray diffraction	A, B, C	8UR, CL	—
5YG1	Plasmodium vivax SHMT bound with PLP-glycine and GS704	x-ray diffraction	A, B, C	PLG, 8UU, CL	12 (best 0.77)
5YG1	Plasmodium vivax shmt bound with plp-glycine and GS704	x-ray diffraction	A, B, C	8UU, CL	—
5YG2	Plasmodium vivax SHMT bound with PLP-glycine and GS705	x-ray diffraction	A, B, C	PLG, N05, CL	13 (best 0.78)
5YG2	Plasmodium vivax shmt bound with plp-glycine and GS705	x-ray diffraction	A, B, C	N05, CL	—
5YG3	Plasmodium vivax SHMT bound with PLP-glycine and S-GS834	x-ray diffraction	A, B, C	PLG, 8UC, CL	13 (best 0.78)
5YG3	Plasmodium vivax shmt bound with plp-glycine and S-GS834	x-ray diffraction	A, B, C	8UC, CL	—
5YG4	Plasmodium vivax SHMT bound with PLP-glycine and S-GS849	x-ray diffraction	A, B, C	8UF, CL	—
5YG4	Plasmodium vivax shmt bound with plp-glycine and S-GS849	x-ray diffraction	A, B, C	8UF, CL	—

Ligands

CL · Chloride ion · in 28 records
PLG · N-glycine-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-yl-methane] · in 11 records
8A0 · (4~{S})-6-azanyl-3-methyl-4-[3-(2-methylphenyl)-5-(trifluoromethyl)phenyl]-4-propan-2-yl-2~{H}-pyrano[2, 3-c]pyrazole-5-carbonitrile · in 2 records
8A3 · 4-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-(trifluoromethyl) phenyl]-~{N}-methyl-~{N}-[2,2,2-tris(fluoranyl) ethyl]benzenesulfonamide · in 2 records
8A6 · 4-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-(trifluoromethyl) phenyl]-~{N}-methyl-~{N}-(phenylmethyl) benzenesulfonamide · in 2 records
8AO · (4~{S})-6-azanyl-3-methyl-4-[3-[4-(phenylmethyl) sulfonylphenyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazole-5-carbonitrile · in 2 records
8AU · (4~{S})-6-azanyl-4-[3-(2-chlorophenyl)-5-(trifluoromethyl)phenyl]-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazole-5-carbonitrile · in 2 records
8B0 · (4~{S})-6-azanyl-4-[3-(2-cyanophenyl)-5-(trifluoromethyl)phenyl]-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazole-5-carbonitrile · in 2 records
8B3 · (4~{S})-6-azanyl-4-[3-(2-fluorophenyl)-5-(trifluoromethyl)phenyl]-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazole-5-carbonitrile · in 2 records
8UC · (3~{S})-6'-azanyl-7-fluoranyl-2,2,3'-trimethyl-5-pyridin-4-yl-spiro[1~{H}-indene-3,4'-2~{H}-pyrano[2,3-c]pyrazole]-5'-carbonitrile · in 2 records
8UF · 2-[1-[(3~{S})-6'-azanyl-5'-cyano-7-fluoranyl-2,2,3'-trimethyl-spiro[1~{H}-indene-3,4'-2~{H}-pyrano[2,3-c]pyrazole]-5-yl]piperidin-4-yl]ethanoic acid · in 2 records
8UL · 1-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-fluoranyl-phenyl]piperidine-4-carboxylic acid · in 2 records
8UO · 2-[1-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-fluoranyl-phenyl]piperidin-4-yl]ethanoic acid · in 2 records
8UR · 2-[1-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-(trifluoromethyl)phenyl]piperidin-4-yl]ethanoic acid · in 2 records
8UU · 3-[1-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-(trifluoromethyl)phenyl]piperidin-4-yl]propanoic acid · in 2 records
N05 · 3-[1-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-fluoranyl-phenyl]piperidin-4-yl]propanoic acid · in 2 records

Elsewhere

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