UniProt A0A133CK16
Serine hydroxymethyltransferase (A0A133CK16)
Serine hydroxymethyltransferase (UniProt A0A133CK16), EC 2.1.2.1: 8 experimental structures on GenesisL1, 7 ligands bound, 47 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A0A133CK16
- Protein
- Serine hydroxymethyltransferase
- EC
- 2.1.2.1
- Experimental structures
- 8
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 47 · 5 records with a druggable one
Structures
8 records of A0A133CK16 in the MolNFT archive: 8 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7V3D | Complex structure of serine hydroxymethyltransferase from Enterococcus faecium and its inhibitor | x-ray diffraction | A, B | 5M5, PLP, CL | 9 (best 0.79) |
| 7V3D | Complex structure of serine hydroxymethyltransferase from enterococcus faecium and its inhibitor | x-ray diffraction | A, B | 5M5, PLP, CL | — |
| 7X5N | Crystal structure of E. faecium SHMT in complex with (+)-SHIN-1 and PLP-Ser | x-ray diffraction | A, B | 5M5, PLS | 7 (best 0.79) |
| 7X5N | Crystal structure of E. faecium shmt in complex with (+)-shin-1 and plp-ser | x-ray diffraction | A, B | 5M5 | — |
| 7X5O | Crystal structure of E. faecium SHMT in complex with Me-THF and PLP-Gly | x-ray diffraction | A, B | THH, PLG | 11 (best 0.77) |
| 7X5O | Crystal structure of E. faecium shmt in complex with me-thf and plp- gly | x-ray diffraction | A, B | — | — |
| 9J4G | Crystal structure of SHMT from E. faecium with (+)-SHIN-2 | x-ray diffraction | A, B | PLS, A1L3N | 7 (best 0.81) |
| 9J4H | Crystal structure of SHMT apo form | x-ray diffraction | A, B, C, D | — | 13 (best 0.88) |
Ligands
- 5M5 · (4R)-6-azanyl-4-[3-(hydroxymethyl)-5-phenyl-phenyl]-3-methyl-4-propan-2-yl-1H-pyrano[2,3-c]pyrazole-5-carbonitrile · in 4 records
- CL · Chloride ion · in 2 records
- PLP · Pyridoxal-5'-phosphate · in 2 records
- PLS · [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine · in 2 records
- A1L3N · (+)-shin-2 · in 1 record
- PLG · N-glycine-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-yl-methane] · in 1 record
- THH · N-[4-({[(6S)-2-amino-4-hydroxy-5-methyl-5,6,7,8-tetrahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid · in 1 record
Elsewhere
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