UniProt A0A0R0IK90

Serine hydroxymethyltransferase (A0A0R0IK90)

Serine hydroxymethyltransferase (UniProt A0A0R0IK90), EC 2.1.2.1: 6 experimental structures on GenesisL1, 3 ligands bound, 93 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt: A0A0R0IK90
Protein: Serine hydroxymethyltransferase
EC: 2.1.2.1
Experimental structures: 6
Predicted models: 0
Ligands: 3
Pockets: 93 · 6 records with a druggable one

Structures

6 records of A0A0R0IK90 in the MolNFT archive: 6 experimental, 0 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
7UJH	Structure of the P130R single variant of serine hydroxymethyltransferase 8 from Glycine max…	x-ray diffraction	A, B	PLG	11 (best 0.77)
7UJI	Structure of the P130R single variant of serine hydroxymethyltransferase 8 from Glycine max…	x-ray diffraction	A, B	—	11 (best 0.76)
8DOM	Structure of the N358Y single variant ofserine hydroxymethyltransferase 8 from Glycine max cultivar…	x-ray diffraction	A, B	—	11 (best 0.79)
8DSK	Structure of the N358Y variant of serine hydroxymethyltransferase 8 in complex with PLP, glycine…	x-ray diffraction	A, B, C, D	PLG, FFO	20 (best 0.81)
8FSD	P130R mutant of soybean SHMT8 in complex with PLP-glycine and formylTHF	x-ray diffraction	A, B, C, D	PLG, FFO	20 (best 0.80)
8TQF	Crystal structure of Soybean SHMT8 in complex with PLP-glycine and diglutamylated…	x-ray diffraction	A, B, C, D	PLG, S8R	20 (best 0.79)

Ligands

PLG · N-glycine-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-yl-methane] · in 4 records
FFO · N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid · in 2 records
S8R · N-[4-({[(6R)-2-amino-5-formyl-4-hydroxy-5,6,7,8-tetrahydropteridin-6-yl]methyl}amino)benzoyl]-L-gamma-glutamyl-L-glutamic acid · in 1 record

Elsewhere

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