UniProt A0A0E8UVJ4
Dihydrofolate reductase (A0A0E8UVJ4)
Dihydrofolate reductase (UniProt A0A0E8UVJ4), EC 1.5.1.3: 16 experimental structures on GenesisL1, 16 ligands bound, 36 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A0A0E8UVJ4
- Protein
- Dihydrofolate reductase
- EC
- 1.5.1.3
- Experimental structures
- 16
- Predicted models
- 0
- Ligands
- 16
- Pockets
- 36 · 10 records with a druggable one
Structures
16 records of A0A0E8UVJ4 in the MolNFT archive: 16 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5U26 | Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218… | x-ray diffraction | A | MMV, NAP, SO4 | 1 (best 0.73) |
| 5U26 | Crystal structure of mycobacterium tuberculosis dihydrofolate reductase bound to NADP and P218… | x-ray diffraction | A | MMV, NAP, SO4 | — |
| 5U27 | Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p65… | x-ray diffraction | A | NAP, P65 | — |
| 5U27 | Crystal structure of mycobacterium tuberculosis dihydrofolate reductase bound to NADP and P65… | x-ray diffraction | A | NAP, P65 | — |
| 6VS5 | Mycobacterium tuberculosis dihydrofolate reductase in complex with… | x-ray diffraction | A, B | CO, 9FH, NDP, PO4 | 3 (best 0.73) |
| 6VS5 | Mycobacterium tuberculosis dihydrofolate reductase in complex with 5… | x-ray diffraction | A, B | CO, 9FH, NDP, PO4 | — |
| 6VS6 | Mycobacterium tuberculosis dihydrofolate reductase in complex with… | x-ray diffraction | A, B | NDP, CO, RKV, PO4 | 3 (best 0.76) |
| 6VS6 | Mycobacterium tuberculosis dihydrofolate reductase in complex with 3… | x-ray diffraction | A, B | NDP, CO, RKV, PO4 | — |
| 6VS8 | Mycobacterium tuberculosis dihydrofolate reductase in complex with ethyl 2-methyl… | x-ray diffraction | A, B | CO, NAP, PO4, RJY, SO4 | 3 (best 0.73) |
| 6VS8 | Mycobacterium tuberculosis dihydrofolate reductase in complex with ethyl 2-methyl… | x-ray diffraction | A, B | CO, NAP, PO4, RJY, SO4 | — |
| 8COP | Mycobacterium tuberculosis dihydrofolate reductase in complex with… | x-ray diffraction | A, B | NDP, PO4, VCI, CO | 4 (best 0.73) |
| 8COQ | Mycobacterium tuberculosis dihydrofolate reductase in complex with… | x-ray diffraction | A, B | NDP, VDT, CO, SO4 | 4 (best 0.72) |
| 8COW | Mycobacterium tuberculosis dihydrofolate reductase in complex with… | x-ray diffraction | A, B | NDP, VB0, CO, SO4 | 4 (best 0.76) |
| 8COX | Mycobacterium tuberculosis dihydrofolate reductase in complex with… | x-ray diffraction | A, B | NDP, PO4, CO, VBJ | 4 (best 0.74) |
| 8CQ8 | Mycobacterium tuberculosis dihydrofolate reductase in complex with methyl… | x-ray diffraction | A, B | VFF, NDP, CO, SO4 | 6 (best 0.72) |
| 8CQ9 | Mycobacterium tuberculosis dihydrofolate reductase in complex with… | x-ray diffraction | A, B | VFU, NDP, CO, SO4 | 4 (best 0.73) |
Ligands
- CO · Cobalt (II) ion · in 12 records
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 10 records
- PO4 · Phosphate ion · in 8 records
- SO4 · Sulfate ion · in 8 records
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 6 records
- 9FH · 5-methyl-1-phenyl-pyrazole-4-carboxylic acid · in 2 records
- MMV · 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl) oxy]propoxy}phenyl)propanoic acid · in 2 records
- P65 · 2,4-diamino-6-methyl-5-[3-(2,4,5-trichlorophenoxy)propyloxy]pyrimidine · in 2 records
- RJY · ethyl 2-methyl-1,3-thiazole-4-carboxylate · in 2 records
- RKV · 3-(furan-2-yl)-1-methyl-1H-pyrazole-5-carboxylic acid · in 2 records
- VB0 · 5-(2-cyclopropylethynyl)-6-(2-fluorophenyl)pyrimidine-2,4-diamine · in 1 record
- VBJ · ~{N}-[3-[2,6-bis(azanyl)-5-(2-cyclopropylethynyl)pyrimidin-4-yl]phenyl]methanesulfonamide · in 1 record
- VCI · ~{N}-[4-[2,6-bis(azanyl)-5-(2-cyclopropylethynyl)pyrimidin-4-yl]phenyl]methanesulfonamide · in 1 record
- VDT · 5-(2-cyclopropylethynyl)-6-(2-methoxyphenyl)pyrimidine-2,4-diamine · in 1 record
- VFF · methyl 4-[2,6-bis(azanyl)-5-(2-cyclopropylethynyl)pyrimidin-4-yl]benzoate · in 1 record
- VFU · 5-[(~{E})-2-cyclopropylethenyl]-6-[4-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.