UniProt A0A029ILG4
Thymidylate synthase (A0A029ILG4)
Thymidylate synthase (UniProt A0A029ILG4), EC 2.1.1.45: 4 experimental structures on GenesisL1, 8 ligands bound, 13 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A0A029ILG4
- Protein
- Thymidylate synthase
- EC
- 2.1.1.45
- Experimental structures
- 4
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 13 · 2 records with a druggable one
Structures
4 records of A0A029ILG4 in the MolNFT archive: 4 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7JX1 | E. coli TSase complex with a bi-substrate reaction intermediate analog | x-ray diffraction | A, B | VLA, TMP, VLD, PO4 | 7 (best 0.75) |
| 7JX1 | E. COLI tsase complex with a bi-substrate reaction intermediate analog | x-ray diffraction | A, B | TMP, PO4 | — |
| 7JXF | E. coli TSase complex with a bi-substrate reaction intermediate diastereomer analog | x-ray diffraction | A, B | 5HU, VMV, NA, VNM | 6 (best 0.76) |
| 7JXF | E. COLI tsase complex with a bi-substrate reaction intermediate diastereomer analog | x-ray diffraction | A, B | 5HU, NA, VNM | — |
Ligands
- 5HU · 5-hydroxymethyluridine-2'-deoxy-5'-monophosphate · in 2 records
- NA · Sodium ion · in 2 records
- PO4 · Phosphate ion · in 2 records
- TMP · Thymidine-5'-phosphate · in 2 records
- VNM · (2S)-2-({4-[({(6S)-2,4-diamino-5-[(1-{(2R,4S,5R)-4-hydroxy-5-[(phosphonooxy)methyl]tetrahydrofuran-2-yl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-5, 6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl}methyl) amino]benzoyl}amino)pentanedioic acid (non-preferred name) · in 2 records
- VLA · N-(4-{[(2,4-diamino-7,8-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino}benzene-1-carbonyl)-L-glutamic acid · in 1 record
- VLD · (2S)-2-({4-[({(6R)-2,4-diamino-5-[(1-{(2R,4S,5R)-4-hydroxy-5-[(phosphonooxy)methyl]tetrahydrofuran-2-yl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl}methyl)amino]benzoyl}amino)pentanedioic acid (non-preferred name) · in 1 record
- VMV · N-[4-({[(6S)-2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl]methyl}amino)benzene-1-carbonyl]-L-glutamic acid · in 1 record
Elsewhere
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