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Ligand · ZEN

ZEN · [4-(6-chloro-naphthalene-2-sulfonyl)-piperazin-1-yl]- (3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl)- methanone

ZEN, [4-(6-chloro-naphthalene-2-sulfonyl)-piperazin-1-yl]- (3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl)- methanone (C25 H27 Cl N4 O3 S, 499.0 g/mol), in the MolNFT structures on GenesisL1: bound in 10 records (5 PDB entries). Every…

Component
ZEN
Formula
C25 H27 Cl N4 O3 S
Class
ligand
Structures
10
PDB entries
5

Binding sites

ZEN in 10 structures; the first of them:

  • 1J17 · Factor xa specific inhibitor in complex with rat trypsin mutant X99/175/190RT · ZEN T1 · binds GLU97, THR98, TYR99, PHE174, ASP189, ALA190, CYS191, GLN192 and 11 more
  • 1QL7 · Factor xa specific inhibitor in complex with bovine trypsin · ZEN A999 · binds ASN97, THR98, LEU99, GLN175, ASP189, SER190, CYS191, GLN192 and 11 more
  • 1QL8 · Factor xa specific inhibitor in complex with bovine trypsin · ZEN A999 · binds TYR151, ASP189, SER190, CYS191, GLN192, SER195, VAL213, SER214 and 5 more
  • 1QL9 · Factor xa specific inhibitor in complex with rat trypsin mutant X99RT · ZEN A999 · binds GLU97, THR98, TYR99, LYS175, ASP189, SER190, CYS191, GLN192 and 11 more
  • 1V2K · Factor XA specific Inhibitor in complex with bovine trypsin variant X(triple.Glu)bT.D2 · ZEN T1 · binds GLU97, THR98, TYR99, PHE174, ASP189, ALA190, CYS191, GLN192 and 11 more
  • 1J17 · Factor xa specific inhibitor in complex with rat trypsin mutant X99/175/190RT · ZEN T1 · binds GLU97, THR98, TYR99, PHE174, ASP189, ALA190, CYS191, GLN192 and 11 more
  • 1QL7 · Factor xa specific inhibitor in complex with bovine trypsin · ZEN A999 · binds ASN97, THR98, LEU99, GLN175, ASP189, SER190, CYS191, GLN192 and 11 more
  • 1QL8 · Factor xa specific inhibitor in complex with bovine trypsin · ZEN A999 · binds TYR151, ASP189, SER190, CYS191, GLN192, SER195, VAL213, SER214 and 5 more
  • 1QL9 · Factor xa specific inhibitor in complex with rat trypsin mutant X99RT · ZEN A999 · binds GLU97, THR98, TYR99, LYS175, ASP189, SER190, CYS191, GLN192 and 11 more
  • 1V2K · Factor xa specific inhibitor in complex with bovine trypsin variant X(TRIPLE.GLU)BT.D2 · ZEN T1 · binds GLU97, THR98, TYR99, PHE174, ASP189, ALA190, CYS191, GLN192 and 11 more

Residues it binds most

GLY 10, SER 10, CYS 10, TYR 10, VAL 10, GLN 10, ASP 10, TRP 10, GLU 6, THR 8 (residue and the binding sites it lines).

Found with

  • CA · Calcium ion
  • SO4 · Sulfate ion

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