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Ligand · V4T

V4T · 1-[(4R,7S)-12-chloro-14-fluoro-13-(2-fluoro-6-hydroxyphenyl)-4-methyl-10-oxa-2,5,16,18-tetrazatetracyclo[9.7.1.0^(2,7).0^(15,19)]nonadeca-1(18),11,13,15(19),16-pentaen-5-en-1-one-yl]prop-2

V4T, 1-[(4R,7S)-12-chloro-14-fluoro-13-(2-fluoro-6-hydroxyphenyl)-4-methyl-10-oxa-2,5,16,18-tetrazatetracyclo[9.7.1.0^(2,7).0^(15,19)]nonadeca-1(18),11,13,15(19),16-pentaen-5-en-1-one-yl]prop-2 (C24 H21 Cl F2 N4 O3, 486.9 g/mol), in the…

Component
V4T
Formula
C24 H21 Cl F2 N4 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

V4T in 2 structures; the first of them:

  • 7O70 · KRasG12C ligand complex · V4T A201 · binds VAL9, GLY10, ALA11, CYS12, LYS16, PRO34, THR58, ALA59 and 12 more
  • 7O70 · KRASG12C ligand complex · V4T A201 · binds VAL9, GLY10, ALA11, CYS12, LYS16, PRO34, THR58, ALA59 and 12 more

Residues it binds most

GLY 4, ALA 4, GLN 4, VAL 4, ARG 4, ASP 4, CYS 4, GLU 4, HIS 4, ILE 4 (residue and the binding sites it lines).

Found with

  • GDP · Guanosine-5'-diphosphate
  • CA · Calcium ion
  • MG · Magnesium ion

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