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Ligand · SKM

SKM · (3R,4S,5R)-3,4,5-trihydroxycyclohex-1-ene-1-carboxylic acid

SKM, (3R,4S,5R)-3,4,5-trihydroxycyclohex-1-ene-1-carboxylic acid (C7 H10 O5, 174.2 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
SKM
Formula
C7 H10 O5
Class
ligand
Structures
4
PDB entries
3

Binding sites

SKM in 4 structures; the first of them:

  • 6HQV · Pentafunctional AROM Complex from Chaetomium thermophilum · SKM A1606 · binds LEU1295, SER1303, SER1305, SER1347, VAL1348, THR1349, LYS1353, ASN1374 and 4 more
  • 5TED · Effector binding domain of quir in complex with shikimate · SKM B401 · binds ILE98, TYR99, THR100, ALA130, THR131, SER149, PHE196, SER200 and 6 more
  • 6BMB · Crystal structure of arabidopsis dehydroquinate dehydratase-shikimate dehydrogenase… · SKM A704 · binds ILE328, SER336, SER338, SER379, CYS380, LYS385, ASN406, ASP423 and 4 more
  • 6HQV · Pentafunctional arom complex from chaetomium thermophilum · SKM A1606 · binds LEU1295, SER1303, SER1305, SER1347, VAL1348, THR1349, LYS1353, ASN1374 and 4 more

Residues it binds most

SER 11, ARG 10, GLN 9, GLY 6, THR 10, ASP 11, TYR 11, LEU 6, ASN 5, ILE 5 (residue and the binding sites it lines).

Found with

  • 3DS · (4S,5R)-4,5-dihydroxy-3-oxocyclohex-1-ene-1-carboxylic acid
  • NAD · Nicotinamide-adenine-dinucleotide
  • ZN · Zinc ion
  • PO4 · Phosphate ion
  • SO4 · Sulfate ion
  • TLA · L(+)-tartaric acid

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