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Ligand · PRL

PRL · Proflavin

PRL, Proflavin (C13 H11 N3, 209.2 g/mol), in the MolNFT structures on GenesisL1: bound in 21 records (11 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
PRL
Formula
C13 H11 N3
Class
ligand
Structures
21
PDB entries
11

Binding sites

PRL in 21 structures; the first of them:

  • 1BCU · Alpha-thrombin complexed with hirugen and proflavin · PRL H280 · binds ASP189, ALA190, CYS191, GLU192, SER195, VAL213, SER214, TRP215 and 4 more
  • 1QVT · Crystal structure of the multidrug binding transcriptional repressor qacr bound to the… · PRL A311 · binds LEU54, GLU57, GLU58, TRP61, THR89, GLU90, TYR93, ILE99 and 2 more
  • 1QVU · Crystal structure of the multidrug binding transcriptional repressor QacR bound to two… · PRL A196 · binds LEU54, GLU57, GLU58, TRP61, THR89, GLU90, TYR93, GLN96 and 3 more
  • 1VTF · Structure of 5'-D(*(BRO)CP*GP*(BRO)CP*G)-3' in complex with proflavine · PRL A12 · binds CBR1, DG2
  • 2KD4 · Solution structure and thermodynamics of 2',5' RNA intercalation · PRL A17 · binds C3, G4, C5, G6
  • 2V57 · Crystal structure of the TetR-like transcriptional regulator LfrR from Mycobacterium… · PRL A1188 · binds HIS67, SER70, ASN71, ILE74, TYR106, PHE121, ASP122, ILE123 and 4 more
  • 3FT6 · Crystal Structure of Proflavine in Complex with a DNA hexamer duplex · PRL A21 · binds DC1, DG2, DC5, DG6
  • 3HTH · Crystal structure of multidrug binding protein EbrR complexed with proflavin · PRL A201 · binds GLY66, PHE67, VAL70, VAL91, LEU92, TRP95, GLU106, TYR107 and 5 more
  • 4ZPH · Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with Proflavine · PRL A501 · binds ARG266, VAL305, GLN306, TRP318, LEU344, SER345, GLU348
  • 7NT4 · X-ray structure of SCoV2-PLpro in complex with small molecule inhibitor · PRL A401 · binds GLY164, ASP165, TYR265, ASN268, TYR269, TYR274
  • 8UTA · yjdF riboswitch from R. gauvreauii in complex with proflavine bound to Fab BL3-6 S97N · PRL N204 · binds A14, U51, U55, A56, U96
  • 1BCU · Alpha-thrombin complexed with hirugen and proflavin · PRL H280 · binds ASP189, ALA190, CYS191, GLU192, SER195, VAL213, SER214, TRP215 and 4 more
  • 1QVT · Crystal structure of the multidrug binding transcriptional repressor qacr bound to the… · PRL A311 · binds LEU54, GLU57, GLU58, TRP61, THR89, GLU90, TYR93, ILE99 and 2 more
  • 1QVU · Crystal structure of the multidrug binding transcriptional repressor qacr bound to two… · PRL A196 · binds LEU54, GLU57, GLU58, TRP61, THR89, GLU90, TYR93, GLN96 and 3 more
  • 1VTF · Structure of 5'-D(*(BRO)CP*GP*(BRO)CP*G)-3' in complex with proflavine · PRL A12 · binds CBR1, DG2
  • 2KD4 · Solution structure and thermodynamics of 2',5' RNA intercalation · PRL A17 · binds C3, G4, C5, G6
  • 2V57 · Crystal structure of the tetr-like transcriptional regulator lfrr from mycobacterium… · PRL A1188 · binds HIS67, SER70, ASN71, ILE74, TYR106, PHE121, ASP122, ILE123 and 4 more
  • 3FT6 · Crystal structure of proflavine in complex with a DNA hexamer duplex · PRL A21 · binds DC1, DG2, DC5, DG6

Residues it binds most

TYR 20, DG 14, TRP 20, GLY 18, ASP 18, CBR 10, GLU 12, LEU 11, CYS 10, ILE 8 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • ET · Ethidium
  • NCO · Cobalt hexammine(iii)
  • NI · Nickel (II) ion
  • ZN · Zinc ion
  • EDO · 1,2-ethanediol
  • IPA · Isopropyl alcohol
  • MG · Magnesium ion

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