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Ligand · PPU

PPU · Puromycin-5'-monophosphate

PPU, Puromycin-5'-monophosphate (C22 H30 N7 O8 P, 551.5 g/mol), in the MolNFT structures on GenesisL1: bound in 13 records (10 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
PPU
Formula
C22 H30 N7 O8 P
Class
ligand
Structures
13
PDB entries
10

Binding sites

PPU in 13 structures; the first of them:

  • 1KQS · The Haloarcula marismortui 50S Complexed with a Pretranslocational Intermediate in… · PPU 476 · binds G2102, A2486, C2487, G2540, U2541, C2542, G2588, C2608 and 5 more
  • 1Q81 · Crystal Structure of minihelix with 3' puromycin bound to A-site of the 50S ribosomal… · PPU 576 · binds G2102, A2103, A2486, C2487, U2541, C2542, G2588, C2608 and 4 more
  • 1Q82 · Crystal Structure of CC-Puromycin bound to the A-site of the 50S ribosomal subunit · PPU 576 · binds G2102, A2103, A2486, C2487, U2541, C2542, G2588, C2608 and 4 more
  • 1FG0 · Large ribosomal subunit complexed with a 13 bp minihelix- puromycin compound · PPU B76 · binds G2102, C2104, A2485, A2486, C2487, U2541, C2542, G2588 and 6 more
  • 1KQS · The haloarcula marismortui 50S complexed with a pretranslocational intermediate in… · PPU 476 · binds G2102, A2486, C2487, G2540, U2541, C2542, G2588, C2608 and 5 more
  • 1NJM · The crystal structure of the 50S large ribosomal subunit from deinococcus radiodurans… · PPU 535 · binds G2044, A2430, C2431, A2482, U2483, G2484, U2485, C2486 and 7 more
  • 1NJO · The crystal structure of the 50S large ribosomal subunit from deinococcus radiodurans… · PPU 535 · binds A2430, C2431, A2482, U2483, G2484, U2485, C2486, C2552 and 5 more
  • 1NJP · The crystal structure of the 50S large ribosomal subunit from deinococcus radiodurans… · PPU 535 · binds A2430, C2431, A2482, U2483, G2484, U2485, C2486, G2532 and 8 more
  • 1Q81 · Crystal structure of minihelix with 3' puromycin bound to a-site of the 50S ribosomal… · PPU 576 · binds G2102, A2103, A2486, C2487, U2541, C2542, G2588, C2608 and 4 more
  • 1Q82 · Crystal structure of cc-puromycin bound to the a-site of the 50S ribosomal subunit · PPU 576 · binds G2102, A2103, A2486, C2487, U2541, C2542, G2588, C2608 and 4 more
  • 1VQL · The structure of the transition state analogue "dcsn" bound to the large ribosomal… · PPU 476 · binds G2102, A2486, C2487, G2540, U2541, C2542, OMG2588, G2618 and 5 more
  • 1VQM · The structure of the transition state analogue "dan" bound to the large ribosomal subunit… · PPU 476 · binds G2102, A2486, C2487, G2540, U2541, C2542, OMG2588, G2618 and 5 more
  • 1VQO · The structure of ccpmn bound to the large ribosomal subunit haloarcula marismortui · PPU 476 · binds G2102, A2486, C2487, G2540, U2541, C2542, OMG2588, G2618 and 3 more

Residues it binds most

C 13, G 13, U 13, A 13, OMG 3, UR3 3, DA 2 (residue and the binding sites it lines).

Found with

  • CD · Cadmium ion
  • K · Potassium ion
  • MG · Magnesium ion
  • NA · Sodium ion
  • CL · Chloride ion
  • SR · Strontium ion
  • ACA · 6-aminohexanoic acid
  • BTN · Biotin
  • PHA · Phenylalaninal
  • PO2 · Hypophosphite
  • SPS · Sparsomycin
  • TSE · Thiophosphonoacetic acid

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