Ligand · SPS

SPS · Sparsomycin

SPS, Sparsomycin (C13 H19 N3 O5 S2, 361.4 g/mol), in the MolNFT structures on GenesisL1: bound in 13 records (8 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component: SPS
Formula: C13 H19 N3 O5 S2
Class: ligand
Structures: 13
PDB entries: 8

Binding sites

SPS in 13 structures; the first of them:

1M90 · Co-crystal structure of CCA-Phe-caproic acid-biotin and sparsomycin bound to the 50S… · SPS 59080 · binds A2486, C2487, U2541, C2608, U2619, U2620, A2637, C9075 and 1 more
1NJM · The crystal structure of the 50S Large ribosomal subunit from Deinococcus radiodurans… · SPS 02881 · binds C2048, G2231, G2232, A2581
1NJN · The crystal structure of the 50S Large ribosomal subunit from Deinococcus radiodurans… · SPS 02881 · binds C2048, G2231, G2232, A2581
1VQ8 · The structure of CCDA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large… · SPS 49701 · binds A2486, C2487, U2541, UR32619, U2620, A2637, C75, DA76
1VQ9 · The structure of CCA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large… · SPS 49701 · binds A2486, C2487, G2540, U2541, UR32619, U2620, A2637, C75 and 1 more
5DGF · Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a… · SPS 13401 · binds A2820, C2821, U2875, U2953, U2954, A2971, CH75, 8AN76
5DGV · Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a… · SPS C3401 · binds A2820, C2821, U2875, U2953, U2954, A2971, C75, 8AN76
5TGM · Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound… · SPS P101 · binds A2820, C2821, U2875, C2942, U2953, U2954, A2971, C75
1M90 · Co-crystal structure of cca-phe-caproic acid-biotin and sparsomycin bound to the 50S… · SPS 59080 · binds A2486, C2487, U2541, C2608, U2619, U2620, A2637, C9075 and 1 more
1NJM · The crystal structure of the 50S large ribosomal subunit from deinococcus radiodurans… · SPS 02881 · binds C2048, G2231, G2232, A2581
1NJN · The crystal structure of the 50S large ribosomal subunit from deinococcus radiodurans… · SPS 02881 · binds C2048, G2231, G2232, A2581
1VQ8 · The structure of ccda-phe-cap-bio and the antibiotic sparsomycin bound to the large… · SPS 49701 · binds A2486, C2487, U2541, UR32619, U2620, A2637, C75, DA76
1VQ9 · The structure of cca-phe-cap-bio and the antibiotic sparsomycin bound to the large… · SPS 49701 · binds A2486, C2487, G2540, U2541, UR32619, U2620, A2637, C75 and 1 more

Residues it binds most

A 16, U 12, C 16, G 6, 8AN 4, UR3 4, CH 2, DA 2 (residue and the binding sites it lines).

Found with

MG · Magnesium ion
CD · Cadmium ion
K · Potassium ion
NA · Sodium ion
CL · Chloride ion
ACA · 6-aminohexanoic acid
SR · Strontium ion
ZN · Zinc ion
OHX · osmium (III) hexammine
PHA · Phenylalaninal
8AN · 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate)
LEU · Leucine

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