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Ligand · JZ8

JZ8 · 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1, 5-a]pyrimidine-3,8-diium

JZ8, 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1, 5-a]pyrimidine-3,8-diium (C16 H15 N5 +2, 277.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å…

Component
JZ8
Formula
C16 H15 N5 +2
Class
ligand
Structures
2
PDB entries
1

Binding sites

JZ8 in 2 structures; the first of them:

  • 6E0B · Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with… · JZ8 A1001 · binds LEU172, CYS175, LEU176, GLY181, CYS184, HIS185, PHE188, LEU189 and 10 more
  • 6E0B · Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with… · JZ8 A1001 · binds LEU172, LEU176, GLY181, CYS184, HIS185, PHE188, LEU189, LEU197 and 7 more

Residues it binds most

LEU 2, CYS 2, ILE 2, PHE 2, ARG 2, GLY 2, HIS 2, MET 2, VAL 2 (residue and the binding sites it lines).

Found with

  • FMN · Flavin mononucleotide
  • ORO · Orotic acid
  • GOL · Glycerol
  • LDA · Lauryl dimethylamine-N-oxide

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