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Ligand · GCG

GCG · Bis(gamma-glutamyl-cysteinyl-glycinyl)spermidine

GCG, Bis(gamma-glutamyl-cysteinyl-glycinyl)spermidine (C27 H49 N9 O10 S2, 723.9 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
GCG
Formula
C27 H49 N9 O10 S2
Class
ligand
Structures
8
PDB entries
4

Binding sites

GCG in 8 structures; the first of them:

  • 1BZL · Crystal structure of trypanosoma cruzi trypanothione reductase in complex with… · GCG A603 · binds SER15, LEU18, GLU19, TRP22, CYS53, VAL54, VAL59, LYS62 and 17 more
  • 2WOW · Trypanosoma brucei trypanothione reductase with NADP and trypanothione bound · GCG A1001 · binds SER14, LEU17, GLU18, TRP21, CYS52, VAL53, VAL58, TYR110 and 10 more
  • 4ADW · Crystal structure of leishmania infantum trypanothione reductase in complex with NADPH… · GCG A1491 · binds PHE396, LEU399, HIS461, PRO462, THR463, SER464, GLU466, GLU467 and 4 more
  • 4GRT · Human glutathione reductase A34E, R37W mutant, mixed disulfide between trypanothione and… · GCG A17 · binds SER30, LEU33, GLU34, TRP37, CYS58, VAL59, VAL64, TYR106 and 6 more
  • 1BZL · Crystal structure of trypanosoma cruzi trypanothione reductase in complex with… · GCG A603 · binds SER15, LEU18, GLU19, TRP22, CYS53, VAL54, VAL59, LYS62 and 17 more
  • 2WOW · Trypanosoma brucei trypanothione reductase with NADP and trypanothione bound · GCG A1001 · binds SER14, LEU17, GLU18, TRP21, CYS52, VAL53, VAL58, TYR110 and 10 more
  • 4ADW · Crystal structure of leishmania infantum trypanothione reductase in complex with NADPH… · GCG A1491 · binds PHE396, LEU399, HIS461, PRO462, THR463, SER464, GLU466, GLU467 and 4 more
  • 4GRT · Human glutathione reductase A34E, R37W mutant, mixed disulfide between trypanothione and… · GCG A17 · binds SER30, LEU33, GLU34, TRP37, CYS58, VAL59, VAL64, TYR106 and 6 more

Residues it binds most

SER 18, GLU 18, VAL 18, THR 18, ILE 16, LEU 18, CYS 16, TYR 16, HIS 16, PHE 16 (residue and the binding sites it lines).

Found with

  • FAD · Flavin-adenine dinucleotide
  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate

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