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Ligand · FYN

FYN · S-{(9R,13S,15R)-17-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-9,13,15-trihydroxy-10,10-dimethyl-13,15-dioxido-4,8-dioxo-12,14,16-trioxa-3,7-diaza-13,15-diphosphaheptadec-1-yl} thioformate

FYN, S-{(9R,13S,15R)-17-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-9,13,15-trihydroxy-10,10-dimethyl-13,15-dioxido-4,8-dioxo-12,14,16-trioxa-3,7-diaza-13,15-diphosphaheptadec-1-yl} thioformate…

Component
FYN
Formula
C22 H36 N7 O17 P3 S
Class
ligand
Structures
5
PDB entries
4

Binding sites

FYN in 5 structures; the first of them:

  • 7PT4 · Actinobacterial 2-hydroxyacyl-CoA lyase (AcHACL) structure in complex with a covalently… · FYN A715 · binds GLN255, GLY270, SER271, ALA272, ARG273, SER274, TYR292, GLN293 and 17 more
  • 8VZC · Crystal Structure of 2-Hydroxyacyl-CoA Lyase/Synthse ApbHACS from Alphaproteobacteria… · FYN A602 · binds PRO242, GLY257, GLY258, ALA259, ARG260, SER261, TRP279, ILE280 and 20 more
  • 8VZD · Crystal Structure of 2-Hydroxyacyl-CoA lyase/synthase TbHACS from Thermoflexaceae… · FYN A602 · binds PRO238, ALA253, ALA254, ALA255, ARG256, SER257, PHE258, TRP275 and 16 more
  • 8VZF · Crystal Structure of 2-Hydroxyacyl-CoA Lyase/Synthase ApbHACS from Alphaproteobacteria… · FYN A601 · binds PRO242, GLY257, GLY258, ALA259, ARG260, SER261, HIS262, TRP279 and 20 more
  • 7PT4 · Actinobacterial 2-hydroxyacyl-CoA lyase (achacl) structure in complex with a covalently… · FYN A715 · binds GLN255, GLY270, SER271, ALA272, ARG273, SER274, TYR292, GLN293 and 12 more

Residues it binds most

GLY 12, ARG 12, ALA 12, GLN 12, TRP 12, MET 10, PHE 9, HIS 10, SER 12, ASP 12 (residue and the binding sites it lines).

Found with

  • TPP · Thiamine diphosphate
  • MG · Magnesium ion
  • ADP · Adenosine-5'-diphosphate
  • SO4 · Sulfate ion
  • EDO · 1,2-ethanediol
  • ACN · Acetone
  • OXT · 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1R,11R, 15S,17R)-19-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-1,11, 15,17-tetrahydroxy-12,12-dimethyl-15,17-dioxido-6,10-dioxo-14,16,18-trioxa-2-thia-5,9-diaza-15,17-diphosphanonadec-1-yl}-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1, 3-thiazol-3-ium
  • PEG · Di(hydroxyethyl)ether
  • A1AEK · 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(hydroxymethyl)-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium
  • CA · Calcium ion
  • CL · Chloride ion
  • PO4 · Phosphate ion

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