Ligand · FID
FID · (2S,4S)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione
FID, (2S,4S)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione (C12 H10 F N3 O4, 279.2 g/mol), in the MolNFT structures on GenesisL1: bound in 21 records (11 PDB entries). Every binding site with its residues within 4.5…
- Component
- FID
- Formula
- C12 H10 F N3 O4
- Class
- ligand
- Structures
- 21
- PDB entries
- 11
Binding sites
FID in 21 structures; the first of them:
- 1EF3 · Fidarestat bound to human aldose reductase · FID A340 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 1PWM · Crystal structure of human Aldose Reductase complexed with NADP and Fidarestat · FID A1320 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 2PD9 · Human aldose reductase mutant V47I complexed with fidarestat. · FID A600 · binds TRP20, ILE47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 2PDW · Human aldose reductase mutant C303D complexed with fidarestat. · FID A600 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 2PDY · Human aldose reductase double mutant S302R-C303D complexed with fidarestat. · FID A600 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 2PEV · Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors… · FID A321 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 2PF8 · Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors… · FID A321 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 2PFH · Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors… · FID A321 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 3H4G · Structure of aldehyde reductase holoenzyme in complex with potent aldose reductase… · FID A2401 · binds TRP22, ILE49, TYR50, TRP82, HIS113, TRP114, PHE125, TRP220 and 3 more
- 4GAB · Human AKR1B10 mutant V301L complexed with NADP+ and fidarestat · FID A402 · binds TRP21, VAL48, TYR49, TRP80, HIS111, TRP112, PHE123, TRP220 and 3 more
- 1EF3 · Fidarestat bound to human aldose reductase · FID A340 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 1PWM · Crystal structure of human aldose reductase complexed with NADP and fidarestat · FID A1320 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 2AGT · Aldose reductase mutant leu 300 pro complexed with fidarestat · FID A320 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 2PD9 · Human aldose reductase mutant V47I complexed with fidarestat. · FID A600 · binds TRP20, ILE47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 2PDW · Human aldose reductase mutant C303D complexed with fidarestat. · FID A600 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 2PDY · Human aldose reductase double mutant S302R-C303D complexed with fidarestat. · FID A600 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 2PEV · Complex of aldose reductase with NADP+ and simaltaneously bound competetive inhibitors… · FID A321 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 2PF8 · Complex of aldose reductase with NADP+ and simaltaneously bound competetive inhibitors… · FID A321 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 2PFH · Complex of aldose reductase with NADP+ and simaltaneously bound competetive inhibitors… · FID A321 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, PHE122, TRP219 and 3 more
- 3H4G · Structure of aldehyde reductase holoenzyme in complex with potent aldose reductase… · FID A2401 · binds TRP22, ILE49, TYR50, TRP82, HIS113, TRP114, PHE125, TRP220 and 3 more
- 4GAB · Human AKR1B10 mutant V301L complexed with NADP+ and fidarestat · FID A402 · binds TRP21, VAL48, TYR49, TRP80, HIS111, TRP112, PHE123, TRP220 and 3 more
Residues it binds most
TRP 23, HIS 23, PHE 23, TYR 23, CYS 21, VAL 21, LEU 20, ALA 19, ILE 4, PRO 3 (residue and the binding sites it lines).
Found with
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