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Ligand · EWW

EWW · 2-chloro-4-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide

EWW, 2-chloro-4-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide (C13 H12 Cl N3 O4 S2, 373.8 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its…

Component
EWW
Formula
C13 H12 Cl N3 O4 S2
Class
ligand
Structures
4
PDB entries
2

Binding sites

EWW in 4 structures; the first of them:

  • 4QSA · Crystal structure of human carbonic anhydrase isozyme II with… · EWW A302 · binds GLN92, HIS94, HIS96, GLU106, HIS119, VAL121, PHE131, VAL135 and 9 more
  • 4QSJ · Crystal structure of human carbonic anhydrase isozyme XIII with… · EWW B302 · binds ARG91, GLN92, HIS94, HIS96, GLU106, HIS119, VAL121, PHE131 and 8 more
  • 4QSA · Crystal structure of human carbonic anhydrase isozyme II with 2… · EWW A302 · binds GLN92, HIS94, HIS96, GLU106, HIS119, VAL121, PHE131, VAL135 and 9 more
  • 4QSJ · Crystal structure of human carbonic anhydrase isozyme xiii with 2… · EWW B302 · binds ARG91, GLN92, HIS94, HIS96, GLU106, HIS119, VAL121, PHE131 and 8 more

Residues it binds most

VAL 6, HIS 6, LEU 6, THR 6, GLU 6, PHE 6, SER 6, TRP 6, GLN 4, PRO 4 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • DMS · Dimethyl sulfoxide
  • PEG · Di(hydroxyethyl)ether
  • NI · Nickel (II) ion
  • CIT · Citric acid
  • EDO · 1,2-ethanediol
  • MES · 2-(N-morpholino)-ethanesulfonic acid

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