Ligand · E1F

E1F · 2-chloro-4-[(pyrimidin-2-ylsulfanyl) acetyl]benzenesulfonamide

E1F, 2-chloro-4-[(pyrimidin-2-ylsulfanyl) acetyl]benzenesulfonamide (C12 H10 Cl N3 O3 S2, 343.8 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the…

Component: E1F
Formula: C12 H10 Cl N3 O3 S2
Class: ligand
Structures: 8
PDB entries: 4

Binding sites

E1F in 8 structures; the first of them:

4KNJ · Crystal structure of human carbonic anhydrase isozyme II with… · E1F A302 · binds GLN92, HIS94, HIS96, GLU106, HIS119, VAL121, PHE131, VAL135 and 10 more
4KNN · Crystal structure of human carbonic anhydrase isozyme XIII with… · E1F B302 · binds ARG93, GLN94, HIS96, HIS98, GLU108, HIS121, VAL123, PHE133 and 8 more
4KP5 · Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with… · E1F A302 · binds GLN89, HIS91, HIS93, GLU104, HIS117, VAL119, ALA129, SER130 and 10 more
6YH5 · Crystal structure of chimeric carbonic anhydrase XII with… · E1F A302 · binds GLN92, HIS94, HIS96, GLU106, HIS119, VAL121, SER135, LEU141 and 10 more
4KNJ · Crystal structure of human carbonic anhydrase isozyme II with 2… · E1F A302 · binds GLN92, HIS94, HIS96, GLU106, HIS119, VAL121, PHE131, VAL135 and 10 more
4KNN · Crystal structure of human carbonic anhydrase isozyme xiii with 2… · E1F B302 · binds ARG93, GLN94, HIS96, HIS98, GLU108, HIS121, VAL123, PHE133 and 8 more
4KP5 · Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with… · E1F A302 · binds GLN89, HIS91, HIS93, GLU104, HIS117, VAL119, ALA129, SER130 and 10 more
6YH5 · Crystal structure of chimeric carbonic anhydrase XII with 2-chloro-4… · E1F A302 · binds HIS94, HIS96, HIS119, VAL121, SER135, LEU141, VAL143, LEU198 and 5 more

Residues it binds most

VAL 16, HIS 16, LEU 16, SER 16, THR 16, PRO 14, TRP 16, GLN 15, GLU 15, ALA 10 (residue and the binding sites it lines).

Found with

ZN · Zinc ion
DMS · Dimethyl sulfoxide
EDO · 1,2-ethanediol
BEZ · Benzoic acid
SO4 · Sulfate ion
ACY · Acetic acid
CIT · Citric acid
MES · 2-(N-morpholino)-ethanesulfonic acid
PEG · Di(hydroxyethyl)ether

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