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Ligand · BRF

BRF · 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methylquinoline-4-carboxylic acid

BRF, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methylquinoline-4-carboxylic acid (C23 H15 F2 N O2, 375.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å…

Component
BRF
Formula
C23 H15 F2 N O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

BRF in 2 structures; the first of them:

  • 1UUO · Rat dihydroorotate dehydrogenase (DHOD)in complex with brequinar · BRF A1397 · binds TYR38, LEU42, MET43, LEU46, GLN47, ASP51, PRO52, ALA55 and 12 more
  • 1UUO · Rat dihydroorotate dehydrogenase (DHOD)IN complex with brequinar · BRF A1397 · binds TYR38, LEU42, MET43, LEU46, GLN47, ASP51, PRO52, ALA55 and 12 more

Residues it binds most

LEU 2, VAL 2, ALA 2, PRO 2, TYR 2, ARG 2, ASP 2, GLN 2, HIS 2, ILE 2 (residue and the binding sites it lines).

Found with

  • FMN · Flavin mononucleotide
  • ORO · Orotic acid
  • NA · Sodium ion
  • NI · Nickel (II) ion

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