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Ligand · ATM

ATM · 3'-azido-3'-deoxythymidine-5'-monophosphate

ATM, 3'-azido-3'-deoxythymidine-5'-monophosphate (C10 H14 N5 O7 P, 347.2 g/mol), in the MolNFT structures on GenesisL1: bound in 22 records (11 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and…

Component
ATM
Formula
C10 H14 N5 O7 P
Class
ligand
Structures
22
PDB entries
11

Binding sites

ATM in 22 structures; the first of them:

  • 1E98 · Wild type human thymidylate kinase complexed with AZTMP and ADP · ATM A301 · binds PHE42, PRO43, ARG45, LEU57, PHE72, ARG76, ASP96, ARG97 and 9 more
  • 1E99 · Human thymidylate kinase complexed with AZTMP and ADP · ATM A301 · binds PHE42, PRO43, ARG45, LEU57, PHE72, ARG76, ASP96, ARG97 and 9 more
  • 1E9B · Human thymidylate kinase complexed with AZTMP and APPNP · ATM A301 · binds ASP15, PHE42, PRO43, ARG45, LEU57, PHE72, ARG76, ARG97 and 9 more
  • 1E9D · Mutant human thymidylate kinase (F105Y) complexed with AZTMP and ADP · ATM A301 · binds ASP15, PHE42, PRO43, ARG45, LEU57, PHE72, ARG76, ASP96 and 9 more
  • 1W2H · Crystal Structure Of Mycobacterium Tuberculosis Thymidylate Kinase Complexed With… · ATM A1209 · binds ASP9, PHE36, PRO37, TYR39, LEU52, PHE70, ARG74, ARG95 and 5 more
  • 2JAU · Crystal structure of D41N variant of human mitochondrial 5'(3')- deoxyribonucleotidase… · ATM A1230 · binds ASN41, ASP43, PHE49, PHE75, TRP76, VAL77, SER78, TRP96 and 10 more
  • 2TMK · Yeast thymidylate kinase complexed with 3'-azido-3'-deoxythymidine monophosphate (azt-mp) · ATM A217 · binds ASP14, LYS18, LYS37, PHE38, PRO39, ARG41, LEU53, PHE69 and 11 more
  • 2WWI · Plasmodium falciparum thymidylate kinase in complex with AZTMP and ADP · ATM A211 · binds ASP17, LYS21, PHE44, PRO45, ARG47, LEU59, PHE74, ARG78 and 8 more
  • 4EAQ · Crystal structure of Thymidylate Kinase from Staphylococcus aureus in complex with… · ATM A301 · binds GLU11, LYS15, ARG36, GLU37, ARG48, PHE66, ARG70, ASP91 and 6 more
  • 4GMD · The crystal structure of thymidylate kinase from Pseudomonas aeruginosa PAO1 in complex… · ATM A301 · binds GLU39, PRO40, ARG50, LEU54, MET70, ARG74, ARG96, PHE97 and 7 more
  • 5HP1 · STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and FOSCARNET, a… · ATM F101 · binds ARG72, ASP110, ASP113, ALA114, TYR115, PHE116, GLN151, MET184 and 5 more
  • 1E98 · Wild type human thymidylate kinase complexed with aztmp and ADP · ATM A301 · binds PHE42, PRO43, ARG45, LEU57, PHE72, ARG76, ASP96, ARG97 and 9 more
  • 1E99 · Human thymidylate kinase complexed with aztmp and ADP · ATM A301 · binds PHE42, PRO43, ARG45, LEU57, PHE72, ARG76, ASP96, ARG97 and 9 more
  • 1E9B · Human thymidylate kinase complexed with aztmp and appnp · ATM A301 · binds ASP15, PHE42, PRO43, ARG45, LEU57, PHE72, ARG76, ARG97 and 9 more
  • 1E9D · Mutant human thymidylate kinase (F105Y) complexed with aztmp and ADP · ATM A301 · binds ASP15, PHE42, PRO43, ARG45, LEU57, PHE72, ARG76, ASP96 and 9 more
  • 1W2H · Crystal structure of mycobacterium tuberculosis thymidylate kinase complexed with… · ATM A1209 · binds ASP9, PHE36, PRO37, TYR39, LEU52, PHE70, ARG74, ARG95 and 5 more
  • 2JAU · Crystal structure of D41N variant of human mitochondrial 5'(3')- deoxyribonucleotidase… · ATM A1230 · binds ASN41, ASP43, PHE49, PHE75, TRP76, VAL77, SER78, TRP96 and 10 more
  • 2TMK · Yeast thymidylate kinase complexed with 3'-azido-3'-deoxythymidine monophosphate (azt-mp) · ATM A217 · binds ASP14, LYS18, LYS37, PHE38, PRO39, ARG41, LEU53, PHE69 and 11 more
  • 2WWI · Plasmodium falciparum thymidylate kinase in complex with aztmp and ADP · ATM A211 · binds ASP17, LYS21, PHE44, PRO45, ARG47, LEU59, PHE74, ARG78 and 8 more
  • 4EAQ · Crystal structure of thymidylate kinase from staphylococcus aureus in complex with… · ATM A301 · binds GLU11, LYS15, ARG36, GLU37, ARG48, PHE66, ARG70, ASP91 and 6 more
  • 4GMD · The crystal structure of thymidylate kinase from pseudomonas aeruginosa PAO1 in complex… · ATM A301 · binds GLU39, PRO40, ARG50, LEU54, MET70, ARG74, ARG96, PHE97 and 7 more

Residues it binds most

ARG 42, PHE 40, TYR 38, ASP 36, GLU 30, SER 28, PRO 32, GLN 30, LEU 30, LYS 18 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • ADP · Adenosine-5'-diphosphate
  • SO4 · Sulfate ion
  • GOL · Glycerol
  • ANP · Phosphoaminophosphonic acid-adenylate ester
  • PPF · Phosphonoformic acid
  • CA · Calcium ion
  • FRU · beta-D-fructofuranose
  • GLC · alpha-D-glucopyranose
  • CL · Chloride ion
  • PO4 · Phosphate ion
  • ACT · Acetate ion

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