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Ligand · 8OG

8OG · 8-oxo-2'-deoxy-guanosine-5'-monophosphate

8OG, 8-oxo-2'-deoxy-guanosine-5'-monophosphate (C10 H14 N5 O8 P, 363.2 g/mol), in the MolNFT structures on GenesisL1: bound in 21 records (12 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and…

Component
8OG
Formula
C10 H14 N5 O8 P
Class
ligand
Structures
21
PDB entries
12

Binding sites

8OG in 21 structures; the first of them:

  • 5GG7 · Crystal structure of Mycobacterium smegmatis MutT1 in complex with 8-oxo-dGTP, 8-oxo-dGMP… · 8OG A402 · binds HIS54, ASP59, TRP61, GLN142, GLN144
  • 5GG8 · Crystal structure of Mycobacterium smegmatis MutT1 in complex with 8-oxo-dGTP, 8-oxo-dGMP… · 8OG A402 · binds HIS54, ASP59, TRP61, ASP141, GLN142, GLN144
  • 7WW9 · Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 1.5 hr in 20 mM Mn2+ · 8OG A202 · binds ILE6, VAL8, ARG23, HIS28, MET29, GLU34, PHE35, PRO36 and 10 more
  • 7WWA · Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 2.5 hr in 20 mM Mn2+ · 8OG A201 · binds ILE6, VAL8, ARG23, HIS28, MET29, GLU34, PHE35, PRO36 and 11 more
  • 7X9H · Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 9 hr using 5 mM Mn2+ · 8OG A203 · binds ILE6, VAL8, ARG23, HIS28, MET29, GLU34, PHE35, PRO36 and 10 more
  • 7X9I · Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 12 hr using 5 mM Mn2+ · 8OG A203 · binds ILE6, VAL8, ARG23, HIS28, MET29, GLU34, PHE35, PRO36 and 10 more
  • 7X9J · Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 24 hr using 5 mM Mn2+ · 8OG A201 · binds ILE6, VAL8, ARG23, HIS28, MET29, GLU34, PHE35, PRO36 and 10 more
  • 7X9K · Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 2 hr using 10 mM Mn2+ · 8OG A202 · binds ILE6, VAL8, ARG23, HIS28, MET29, GLU34, PHE35, PRO36 and 10 more
  • 7X9L · Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 4 hr using 10 mM Mn2+ · 8OG A201 · binds ILE6, VAL8, ARG23, HIS28, MET29, GLU34, PHE35, PRO36 and 11 more
  • 7X9N · Crystal structure of MutT-8-oxo-dGTP complex with three Mg2+ ions: Reaction using Mg2+ · 8OG A203 · binds ILE6, VAL8, ARG23, HIS28, MET29, GLU34, PHE35, PRO36 and 11 more
  • 7X9O · Crystal structure of MutT-8-oxo-dGMP complex with Mg2+ ions: Reaction using Mg2+ · 8OG A201 · binds ILE6, VAL8, ARG23, HIS28, MET29, GLU34, PHE35, PRO36 and 12 more
  • 8I8S · Crystal structure of human MTH1(G2K mutant) in complex with 8-oxo-dGMP and Mn2+ · 8OG A201 · binds TYR7, THR8, LEU9, LYS23, PHE27, ASN33, PHE35, GLY36 and 11 more
  • 7WW9 · Crystal structure of mutt-8-oxo-dgtp complex: reaction for 1.5 hr in 20 mm MN2+ · 8OG A202 · binds ILE6, VAL8, ARG23, HIS28, GLU34, PHE35, GLY37, GLY38 and 6 more
  • 7WWA · Crystal structure of mutt-8-oxo-dgtp complex: reaction for 2.5 hr in 20 mm MN2+ · 8OG A201 · binds ILE6, VAL8, ARG23, HIS28, GLU34, PHE35, GLY37, GLY38 and 6 more
  • 7X9H · Crystal structure of mutt-8-oxo-dgtp complex: reaction for 9 hr using 5 mm MN2+ · 8OG A203 · binds ILE6, VAL8, ARG23, HIS28, GLU34, PHE35, GLY37, GLY38 and 7 more
  • 7X9I · Crystal structure of mutt-8-oxo-dgtp complex: reaction for 12 hr using 5 mm MN2+ · 8OG A203 · binds ILE6, VAL8, ARG23, HIS28, GLU34, PHE35, GLY37, GLY38 and 6 more
  • 7X9J · Crystal structure of mutt-8-oxo-dgtp complex: reaction for 24 hr using 5 mm MN2+ · 8OG A201 · binds ILE6, VAL8, ARG23, HIS28, GLU34, PHE35, GLY37, GLY38 and 6 more
  • 7X9K · Crystal structure of mutt-8-oxo-dgtp complex: reaction for 2 hr using 10 mm MN2+ · 8OG A202 · binds ILE6, VAL8, ARG23, HIS28, GLU34, PHE35, GLY37, GLY38 and 6 more
  • 7X9L · Crystal structure of mutt-8-oxo-dgtp complex: reaction for 4 hr using 10 mm MN2+ · 8OG A201 · binds ILE6, VAL8, ARG23, HIS28, GLU34, PHE35, GLY37, GLY38 and 6 more
  • 7X9N · Crystal structure of mutt-8-oxo-dgtp complex with three MG2+ ions: reaction using MG2+ · 8OG A203 · binds ILE6, VAL8, ARG23, HIS28, GLU34, PHE35, GLY37, GLY38 and 7 more
  • 7X9O · Crystal structure of mutt-8-oxo-dgmp complex with MG2+ ions: reaction using MG2+ · 8OG A201 · binds ILE6, VAL8, ARG23, HIS28, GLU34, PHE35, GLY37, GLY38 and 6 more

Residues it binds most

PHE 20, GLY 20, ILE 18, ARG 18, PRO 18, GLU 20, HIS 21, ASN 20, LEU 20, VAL 20 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • MN · Manganese (II) ion
  • NA · Sodium ion
  • FRU · beta-D-fructofuranose
  • GLC · alpha-D-glucopyranose
  • 8DG · 8-oxo-2'-deoxyguanosine-5'-triphosphate
  • MG · Magnesium ion
  • POP · Pyrophosphate 2-

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