Ligand · 8I4

8I4 · (2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid

8I4, (2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid (C7 H12 O7, 208.2 g/mol), in the MolNFT structures on GenesisL1: bound in 14 records (8 PDB entries). Every binding site with its residues within 4.5 Å, the…

Component: 8I4
Formula: C7 H12 O7
Class: ligand
Structures: 14
PDB entries: 8

Binding sites

8I4 in 14 structures; the first of them:

7PR9 · Crystal structure of Burkholderia pseudomallei heparanase in complex with covalent… · 8I4 C1 · binds GLU36, GLY68, ASN69, ASN143, GLU144, TYR215, GLU255, TRP260 and 4 more
7PRB · Crystal structure of Burkholderia pseudomallei heparanase in complex with covalent… · 8I4 C1 · binds GLU36, GLY68, ASN69, ASN143, GLU144, TYR215, GLU255, TRP260 and 4 more
7PRT · Crystal structure of human heparanase in complex with covalent inhibitor CB678 · 8I4 D1 · binds ASN224, GLU225, TYR298, GLU343, TYR348, GLY349, GLY350, GLN383 and 5 more
7PSI · Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in complex with… · 8I4 A501 · binds GLU45, GLY79, ASN80, PRO104, ASP105, ASN172, GLU173, TYR243 and 7 more
7PSJ · Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in complex with… · 8I4 B1 · binds GLU45, GLY79, ASN80, ASN172, GLU173, TYR243, GLU287, TYR292 and 4 more
7PSK · Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in complex with… · 8I4 B1 · binds GLU45, GLY79, ASN80, ASN172, GLU173, TYR243, GLU287, TYR292 and 4 more
7PR7 · Crystal structure of human heparanase in complex with covalent inhibitor VL166 · 8I4 D1 · binds ASN224, GLU225, TYR298, GLU343, TYR348, GLY349, GLY350, GLN383 and 4 more
7PR8 · Crystal structure of human heparanase in complex with covalent inhibitor GR109 · 8I4 D1 · binds ASN224, GLU225, TYR298, GLU343, TYR348, GLY349, GLY350, GLN383 and 4 more
7PR9 · Crystal structure of burkholderia pseudomallei heparanase in complex with covalent… · 8I4 C1 · binds GLU36, GLY68, ASN69, ASN143, GLU144, TYR215, GLU255, TRP260 and 4 more
7PRB · Crystal structure of burkholderia pseudomallei heparanase in complex with covalent… · 8I4 C1 · binds GLU36, GLY68, ASN69, ASN143, GLU144, TYR215, GLU255, TRP260 and 4 more
7PRT · Crystal structure of human heparanase in complex with covalent inhibitor CB678 · 8I4 D1 · binds ASN224, GLU225, TYR298, GLU343, TYR348, GLY349, GLY350, GLN383 and 4 more
7PSI · Crystal structure of beta-glucuronidase from acidobacterium capsulatum in complex with… · 8I4 A501 · binds GLU45, GLY79, ASN80, PRO104, ASP105, ASN172, GLU173, TYR243 and 6 more
7PSJ · Crystal structure of beta-glucuronidase from acidobacterium capsulatum in complex with… · 8I4 B1 · binds GLU45, GLY79, ASN80, ASN172, GLU173, TYR243, GLU287, TYR292 and 4 more
7PSK · Crystal structure of beta-glucuronidase from acidobacterium capsulatum in complex with… · 8I4 B1 · binds GLU45, GLY79, ASN80, ASN172, GLU173, TYR243, GLU287, TYR292 and 4 more

Residues it binds most

GLU 18, GLY 18, TYR 18, ASN 18, HIS 14, GLN 10, TRP 8, ASP 6, THR 4, PRO 2 (residue and the binding sites it lines).

Found with

EDO · 1,2-ethanediol
NGY · 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose
NDG · 2-acetamido-2-deoxy-alpha-D-glucopyranose
FUC · alpha-L-fucopyranose
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
CL · Chloride ion
Z61 · 2-deoxy-alpha-D-arabino-hexopyranose
SO4 · Sulfate ion

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.