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Ligand · 4AM

4AM · 4-amino-2-deoxy-2,3-dehydro-N-acetyl-neuraminic acid

4AM, 4-amino-2-deoxy-2,3-dehydro-N-acetyl-neuraminic acid (C11 H18 N2 O7, 290.3 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
4AM
Formula
C11 H18 N2 O7
Class
sugar
Structures
3
PDB entries
3

Binding sites

4AM in 3 structures; the first of them:

  • 1F8C · Native Influenza Neuraminidase in Complex with 4-amino-2-deoxy-2,3-dehydro-N-neuraminic… · 4AM A4 · binds ARG118, GLU119, ASP151, ARG152, TRP178, SER179, ILE222, ARG224 and 9 more
  • 2QWD · The X-ray structure of a complex of 4-amino-NEU5AC2EN and a drug resistant variant R292K… · 4AM A800 · binds ARG118, GLU119, ASP151, ARG152, TRP178, SER179, ILE222, ARG224 and 8 more
  • 8GFM · Crystal structure of soluble lytic transglycosylase Cj0843 of Campylobacter jejuni in… · 4AM A601 · binds GLU390, ALA403, MET407, GLN408, PHE409, MET410, LEU413, HIS445 and 5 more

Residues it binds most

ARG 2, GLU 3, GLY 3, TYR 3, ALA 3, ASN 3, ASP 2, ILE 2, MET 1, SER 2 (residue and the binding sites it lines).

Found with

  • CA · Calcium ion
  • MAN · alpha-D-mannopyranose
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • BMA · beta-D-mannopyranose
  • CIT · Citric acid

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