GL1X · GenesisL1 explorer

Ligand · 2WZ

2WZ · N-[(R)-(2-amino-5-chloro-3-fluoropyridin-4-yl){7-[4-(2-hydroxypropan-2-yl)pyridin-2-yl]-1-benzothiophen-2-yl}methyl]cyclopropanesulfonamide

2WZ, N-[(R)-(2-amino-5-chloro-3-fluoropyridin-4-yl){7-[4-(2-hydroxypropan-2-yl)pyridin-2-yl]-1-benzothiophen-2-yl}methyl]cyclopropanesulfonamide (C25 H24 Cl F N4 O3 S2, 547.1 g/mol), in the MolNFT structures on GenesisL1: bound in 2…

Component
2WZ
Formula
C25 H24 Cl F N4 O3 S2
Class
ligand
Structures
2
PDB entries
1

Binding sites

2WZ in 2 structures; the first of them:

  • 4PX5 · Human GKRP bound to AMG-0696 and Sorbitol-6-phosphate · 2WZ A701 · binds HIS9, VAL10, ILE11, TYR24, ALA27, VAL28, PRO29, GLU32 and 18 more
  • 4PX5 · Human gkrp bound to amg-0696 and sorbitol-6-phosphate · 2WZ A701 · binds HIS9, VAL10, ILE11, TYR24, ALA27, VAL28, PRO29, GLU32 and 18 more

Residues it binds most

ALA 4, ARG 4, ASN 4, HIS 4, LYS 4, MET 4, SER 4, VAL 4, ASP 4, GLU 4 (residue and the binding sites it lines).

Found with

  • S6P · D-sorbitol-6-phosphate
  • IOD · Iodide ion
  • SO4 · Sulfate ion
  • GOL · Glycerol

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