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Ligand · 2UY

2UY · (2S)-2-{6'-[(6-aminopyridin-3-yl)sulfonyl]-2'-(phenylamino)-2,3'-bipyridin-5-yl}-1,1,1-trifluoropropan-2-ol

2UY, (2S)-2-{6'-[(6-aminopyridin-3-yl)sulfonyl]-2'-(phenylamino)-2,3'-bipyridin-5-yl}-1,1,1-trifluoropropan-2-ol (C24 H20 F3 N5 O3 S, 515.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
2UY
Formula
C24 H20 F3 N5 O3 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

2UY in 2 structures; the first of them:

  • 4OP3 · Human GKRP bound to AMG-5112 and Sorbitol-6-phosphate · 2UY A701 · binds HIS9, ILE11, TYR24, ALA27, VAL28, PRO29, GLU32, SER34 and 15 more
  • 4OP3 · Human gkrp bound to amg-5112 and sorbitol-6-phosphate · 2UY A701 · binds HIS9, ILE11, TYR24, ALA27, VAL28, PRO29, GLU32, SER34 and 15 more

Residues it binds most

ALA 4, ARG 4, SER 4, HIS 4, MET 4, ASN 4, ASP 4, GLU 4, GLY 4, ILE 4 (residue and the binding sites it lines).

Found with

  • S6P · D-sorbitol-6-phosphate
  • IOD · Iodide ion
  • SO4 · Sulfate ion
  • GOL · Glycerol

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