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Ligand · 2UW

2UW · (2S)-2-(6-{5-[(6-aminopyridin-3-yl)sulfonyl]thiophen-2-yl}-5-chloropyridin-3-yl)-1,1,1-trifluoropropan-2-ol

2UW, (2S)-2-(6-{5-[(6-aminopyridin-3-yl)sulfonyl]thiophen-2-yl}-5-chloropyridin-3-yl)-1,1,1-trifluoropropan-2-ol (C17 H13 Cl F3 N3 O3 S2, 463.9 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component
2UW
Formula
C17 H13 Cl F3 N3 O3 S2
Class
ligand
Structures
2
PDB entries
1

Binding sites

2UW in 2 structures; the first of them:

  • 4OP1 · GKRP bound to AMG0556 and Sorbitol-6-Phosphate · 2UW A701 · binds HIS9, TYR24, VAL28, PRO29, GLU32, LYS33, SER34, GLY181 and 14 more
  • 4OP1 · Gkrp bound to AMG0556 and sorbitol-6-phosphate · 2UW A701 · binds HIS9, TYR24, VAL28, PRO29, GLU32, LYS33, SER34, GLY181 and 14 more

Residues it binds most

ARG 4, SER 4, ALA 4, LYS 4, MET 4, HIS 4, ASN 4, ASP 4, GLU 4, GLY 4 (residue and the binding sites it lines).

Found with

  • S6P · D-sorbitol-6-phosphate
  • IOD · Iodide ion
  • SO4 · Sulfate ion
  • GOL · Glycerol

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