Ligand · 2TO

2TO · 2-(2-{4-[(6-aminopyridin-3-yl)sulfonyl]piperazin-1-yl}-3,3'-bipyridin-5-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol

2TO, 2-(2-{4-[(6-aminopyridin-3-yl)sulfonyl]piperazin-1-yl}-3,3'-bipyridin-5-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol (C22 H20 F6 N6 O3 S, 562.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component: 2TO
Formula: C22 H20 F6 N6 O3 S
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

2TO in 2 structures; the first of them:

4OLH · Human GKRP Bound to AMG5106 and Sorbitol-6-Phosphate · 2TO A701 · binds TYR24, ALA27, VAL28, PRO29, GLU32, LYS33, SER34, GLY181 and 15 more
4OLH · Human gkrp bound to AMG5106 and sorbitol-6-phosphate · 2TO A701 · binds TYR24, ALA27, VAL28, PRO29, GLU32, LYS33, SER34, GLY181 and 15 more

Residues it binds most

ALA 4, ARG 4, SER 4, LYS 4, MET 4, ASN 4, ASP 4, GLU 4, GLY 4, HIS 4 (residue and the binding sites it lines).

Found with

S6P · D-sorbitol-6-phosphate
IOD · Iodide ion
SO4 · Sulfate ion
GOL · Glycerol

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