GL1X · GenesisL1 explorer

Ligand · 2TE

2TE · (2R)-2-{4-[(2S)-4-[(6-aminopyridin-3-yl)sulfonyl]-2-(prop-1-yn-1-yl)piperazin-1-yl]phenyl}-1,1,1-trifluorohex-4-yn-2-ol

2TE, (2R)-2-{4-[(2S)-4-[(6-aminopyridin-3-yl)sulfonyl]-2-(prop-1-yn-1-yl)piperazin-1-yl]phenyl}-1,1,1-trifluorohex-4-yn-2-ol (C24 H25 F3 N4 O3 S, 506.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
2TE
Formula
C24 H25 F3 N4 O3 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

2TE in 2 structures; the first of them:

  • 4OHK · Human GKRP bound to AMG-2526 and S6P · 2TE A701 · binds VAL10, TYR24, VAL28, PRO29, GLU32, LYS33, SER34, GLY181 and 17 more
  • 4OHK · Human gkrp bound to amg-2526 and S6P · 2TE A701 · binds VAL10, TYR24, VAL28, PRO29, GLU32, LYS33, SER34, GLY181 and 17 more

Residues it binds most

ARG 4, SER 4, ALA 4, LYS 4, MET 4, LEU 4, VAL 4, ASN 4, ASP 4, GLN 4 (residue and the binding sites it lines).

Found with

  • S6P · D-sorbitol-6-phosphate
  • IOD · Iodide ion
  • SO4 · Sulfate ion
  • GOL · Glycerol

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