MolNFT v2 · #51068 · protein

Crystal structure of Nasturtium xyloglucan hydrolase isoform NXG2

2UWC · Cellulase: “Crystal structure of Nasturtium xyloglucan hydrolase isoform NXG2”. X-ray diffraction at 2.3, 6 pockets (best druggability 0.56). MolNFT v2 #51068 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2UWC
Type: protein
Length: 531 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.3
Source: TROPAEOLUM MAJUS
Molecule: Cellulase
EC: 3.2.1.151, 3.2.1.4
UniProt: Q07524
Pockets: 6 · best druggability 0.56

Structure

x-ray diffraction · resolution 2.3 · 2 distinct chains · 14% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cellulase (EC 3.2.1.151, 3.2.1.4)	protein	266	15% helix, 41% strand	Q07524
B	Cellulase (EC 3.2.1.151, 3.2.1.4)	protein	265	14% helix, 42% strand	Q07524

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	72	0.56	0.88	20	empty
2	284	0.56	0.76	41	empty
3	57	0.54	0.88	20	empty
4	252	0.53	0.76	40	empty
5	97	0.38	0.75	15	empty

Interfaces

1 interface between chains.

A–B · 615 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

2UWC · Crystal structure of nasturtium xyloglucan hydrolase isoform NXG2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07524
Elsewhere: RCSB PDB 2UWC · PDBe 2UWC · UniProt Q07524

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