MolNFT v1 · #51060 · protein
Crystal structure of nasturtium xyloglucan hydrolase isoform NXG2
2UWC · Cellulase: “Crystal structure of nasturtium xyloglucan hydrolase isoform NXG2”. X-ray diffraction, 6 pockets (best druggability 0.56). MolNFT v1 #51060 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2UWC
- Type
- protein
- Length
- 531 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cellulase
- EC
- 3.2.1.151, 3.2.1.4
- UniProt
- Q07524
- Pockets
- 6 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 14% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cellulase (EC 3.2.1.151, 3.2.1.4) | protein | 266 | 15% helix, 41% strand | Q07524 |
| B | Cellulase (EC 3.2.1.151, 3.2.1.4) | protein | 265 | 14% helix, 42% strand | Q07524 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.56 | 0.88 | 20 | empty |
| 2 | 284 | 0.56 | 0.76 | 41 | empty |
| 3 | 57 | 0.54 | 0.88 | 20 | empty |
| 4 | 252 | 0.53 | 0.76 | 40 | empty |
| 5 | 97 | 0.38 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 615 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 2UWC · Crystal structure of Nasturtium xyloglucan hydrolase isoform NXG2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07524
- Elsewhere: RCSB PDB 2UWC · PDBe 2UWC · UniProt Q07524
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