MolNFT v2 · #31588 · protein
Crystal structure for the mutant W136E of Sulfolobus solfataricus hexaprenyl pyrophosphate synthase
2AZK · Geranylgeranyl pyrophosphate synthetase: “Crystal structure for the mutant W136E of Sulfolobus solfataricus hexaprenyl pyrophosphate synthase”. X-ray diffraction at 2.7, 5 pockets (best druggability 0.81). MolNFT v2 #31588 on…
- PDB
- 2AZK
- Type
- protein
- Length
- 552 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.7
- Source
- Sulfolobus solfataricus
- Molecule
- Geranylgeranyl pyrophosphate synthetase
- EC
- 2.5.1.1
- Pockets
- 5 · best druggability 0.81
Structure
x-ray diffraction · resolution 2.7 · 1 distinct chain · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Geranylgeranyl pyrophosphate synthetase (EC 2.5.1.1) | protein | 276 | 81% helix, 0% strand | — |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 644 | 0.81 | 0.85 | 70 | empty |
| 2 | 336 | 0.67 | 0.82 | 41 | empty |
| 3 | 75 | 0.57 | 0.87 | 15 | empty |
| 4 | 82 | 0.40 | 0.78 | 16 | empty |
| 5 | 56 | 0.26 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1897 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 2AZK · Crystal structure for the mutant W136E of sulfolobus solfataricus hexaprenyl… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2AZK · PDBe 2AZK
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