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Crystal structure for the mutant W136E of Sulfolobus solfataricus hexaprenyl pyrophosphate synthase

Analyse Crystal structure for the mutant W136E of Sulfolobus solfataricus hexaprenyl… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2AZK
Type: protein
Length: 552 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.7
Source: Sulfolobus solfataricus
Molecule: Geranylgeranyl pyrophosphate synthetase
EC: 2.5.1.1
Pockets: 5 · best druggability 0.81

Structure

x-ray diffraction · resolution 2.7 · 1 distinct chain · 81% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Geranylgeranyl pyrophosphate synthetase (EC 2.5.1.1)	protein	276	81% helix, 0% strand	—

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	644	0.81	0.85	70	empty
2	336	0.67	0.82	41	empty
3	75	0.57	0.87	15	empty
4	82	0.40	0.78	16	empty
5	56	0.26	0.73	15	empty

Interfaces

1 interface between chains.

A–B · 1897 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

2AZK · Crystal structure for the mutant W136E of sulfolobus solfataricus hexaprenyl… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2AZK · PDBe 2AZK

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