MolNFT v2 · #226184 · protein

Crystal structure of human serum albumin in complex with ALB8(VHH) domain of ozoralizumab

8Z8V: “Crystal structure of human serum albumin in complex with ALB8(VHH) domain of ozoralizumab”. X-ray diffraction at 2.05, 8 pockets (best druggability 0.84). MolNFT v2 #226184 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 8Z8V
Type: protein
Length: 688 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.05
Source: Homo sapiens
Molecule: Serum albumin; ALB8:VHH
UniProt: P02768
Pockets: 8 · best druggability 0.84

Structure

x-ray diffraction · resolution 2.05 · 2 distinct chains · 63% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serum albumin	protein	573	74% helix, 0% strand	P02768
B	ALB8:VHH	protein	115	8% helix, 47% strand	—

Pockets

8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	600	0.84	0.88	65	empty
2	103	0.67	0.90	23	empty
3	203	0.67	0.85	23	empty
4	192	0.66	0.85	25	empty
5	146	0.59	0.83	19	empty

Interfaces

1 interface between chains.

A–B · 663 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 18 disulfide (disulfide).

Compared structures

P02768 · AlphaFold monomer V2.0 prediction for albumin (P02768) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02768
Elsewhere: RCSB PDB 8Z8V · PDBe 8Z8V · UniProt P02768

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