Research workbench

Crystal structure of human serum albumin in complex with ALB8(VHH) domain of ozoralizumab

Analyse Crystal structure of human serum albumin in complex with ALB8(VHH) domain of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 8Z8V
Type: protein
Length: 688 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.05
Source: Homo sapiens
Molecule: Serum albumin; ALB8:VHH
UniProt: P02768
Pockets: 8 · best druggability 0.84

Structure

x-ray diffraction · resolution 2.05 · 2 distinct chains · 63% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serum albumin	protein	573	74% helix, 0% strand	P02768
B	ALB8:VHH	protein	115	8% helix, 47% strand	—

Pockets

8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	600	0.84	0.88	65	empty
2	103	0.67	0.90	23	empty
3	203	0.67	0.85	23	empty
4	192	0.66	0.85	25	empty
5	146	0.59	0.83	19	empty

Interfaces

1 interface between chains.

A–B · 663 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 18 disulfide (disulfide).

Compared structures

P02768 · AlphaFold monomer V2.0 prediction for albumin (P02768) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02768
Elsewhere: RCSB PDB 8Z8V · PDBe 8Z8V · UniProt P02768

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.