MolNFT v2 · #224524 · protein

Structure of WDR5 in complex with WIN motif containing SET1B

8WXV · WD repeat-containing protein 5: “Structure of WDR5 in complex with WIN motif containing SET1B”. X-ray diffraction at 2.4, 4 pockets (best druggability 0.84). MolNFT v2 #224524 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 8WXV
Type: protein
Length: 617 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.4
Source: Homo sapiens
Molecule: WD repeat-containing protein 5; SET1B
UniProt: P61964
Pockets: 4 · best druggability 0.84

Structure

x-ray diffraction · resolution 2.4 · 3 distinct chains · 1% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	WD repeat-containing protein 5	protein	301	0% helix, 51% strand	P61964
B, D	SET1B	protein	8	50% helix, 0% strand	—
C	WD repeat-containing protein 5	protein	300	0% helix, 51% strand	P61964

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	879	0.84	0.86	66	empty
2	469	0.73	0.82	46	empty
3	218	0.55	0.78	29	empty
4	56	0.30	0.75	14	empty

Interfaces

3 interfaces between chains.

A–B · 585 Å² buried · 9 hydrogen bonds · protein-protein
C–D · 576 Å² buried · 10 hydrogen bonds · protein-protein
A–C · 455 Å² buried · 1 hydrogen bond · protein-protein

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61964
Elsewhere: RCSB PDB 8WXV · PDBe 8WXV · UniProt P61964

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