MolNFT v2 · #224251 · protein
Cryo EM map of SLC7A10 in the apo state
8WNS · Amino acid transporter heavy chain SLC3A2: “Cryo EM map of SLC7A10 in the apo state”. Electron microscopy at 3.42, 1 ligand (NAG), 14 pockets (best druggability 0.69). MolNFT v2 #224251 on GenesisL1: 3D structure, binding sites and…
- PDB
- 8WNS
- Type
- protein
- Length
- 924 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.42
- Source
- Homo sapiens
- Molecule
- Amino acid transporter heavy chain SLC3A2; Asc-type amino acid transporter 1
- UniProt
- P08195, Q9NS82
- Ligands
- NAG
- Pockets
- 14 · best druggability 0.69
Structure
electron microscopy · resolution 3.42 · 2 distinct chains · 56% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Amino acid transporter heavy chain SLC3A2 | protein | 468 | 36% helix, 15% strand | P08195 |
| B | Asc-type amino acid transporter 1 | protein | 456 | 76% helix, 1% strand | Q9NS82 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.69 | 0.97 | 16 | empty |
| 2 | 345 | 0.65 | 0.80 | 37 | empty |
| 3 | 417 | 0.62 | 0.76 | 27 | empty |
| 4 | 177 | 0.61 | 0.83 | 29 | empty |
| 5 | 251 | 0.55 | 0.77 | 34 | empty |
Interfaces
1 interface between chains.
- A–B · 1369 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 glycan, 1 disulfide (N-glycosylation, disulfide).
Compared structures
- Q9NS82 · AlphaFold monomer V2.0 prediction for asc-type amino acid transporter 1 (Q9NS82) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P08195 · AlphaFold monomer V2.0 prediction for 4F2 cell-surface antigen heavy chain (P08195) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08195
- Every structure of UniProt Q9NS82
- Elsewhere: RCSB PDB 8WNS · PDBe 8WNS · UniProt P08195 · UniProt Q9NS82
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