MolNFT v2 · #223212 · protein
Cryo-EM structure of short form insulin receptor (IR-A) with three IGF2 bound, asymmetric conformation.
8VJC · Isoform Short of Insulin receptor: “Cryo-EM structure of short form insulin receptor (IR-A) with three IGF2 bound, asymmetric conformation.”. Electron microscopy at 3.8, 20 pockets (best druggability 0.86). MolNFT v2 #223212 on…
- PDB
- 8VJC
- Type
- protein
- Length
- 1,726 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.8
- Source
- Homo sapiens
- Molecule
- Isoform Short of Insulin receptor; Insulin-like growth factor II
- EC
- 2.7.10.1
- UniProt
- P06213, P01344
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · resolution 3.8 · 5 distinct chains · 12% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform Short of Insulin receptor (EC 2.7.10.1) | protein | 787 | 10% helix, 31% strand | P06213 |
| B | Isoform Short of Insulin receptor (EC 2.7.10.1) | protein | 802 | 10% helix, 31% strand | P06213 |
| C | Insulin-like growth factor II | protein | 42 | 33% helix, 5% strand | P01344 |
| D | Insulin-like growth factor II | protein | 54 | 28% helix, 4% strand | P01344 |
| E | Insulin-like growth factor II | protein | 41 | 37% helix, 0% strand | P01344 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 350 | 0.86 | 0.94 | 49 | empty |
| 2 | 1096 | 0.79 | 0.81 | 98 | empty |
| 3 | 672 | 0.71 | 0.78 | 61 | empty |
| 4 | 492 | 0.69 | 0.80 | 41 | empty |
| 5 | 54 | 0.65 | 0.95 | 20 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1896 Ų buried · 13 hydrogen bonds · protein-protein
- A–D · 899 Ų buried · 13 hydrogen bonds · protein-protein
- B–E · 867 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 656 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 407 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 41 disulfide (disulfide).
Compared structures
- P06213 · AlphaFold monomer V2.0 prediction for insulin receptor (P06213) · a predicted model of the same protein · chain A against A, TM-score 0.82
- P01344 · AlphaFold monomer V2.0 prediction for insulin-like growth factor II (P01344) · a predicted model of the same protein · chain C against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06213
- Every structure of UniProt P01344
- Elsewhere: RCSB PDB 8VJC · PDBe 8VJC · UniProt P06213 · UniProt P01344
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