MolNFT v2 · #221335 · protein
Human PI3K p85alpha/p110alpha
8TS7 · Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic…: “Human PI3K p85alpha/p110alpha”. X-ray diffraction at 2.71, 20 pockets (best druggability 0.87). MolNFT v2 #221335 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 8TS7
- Type
- protein
- Length
- 1,263 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.71
- Source
- Homo sapiens
- Molecule
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform…
- UniProt
- P42336, P27986
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · resolution 2.71 · 2 distinct chains · 47% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | protein | 997 | 43% helix, 19% strand | P42336 |
| B | Phosphatidylinositol 3-kinase regulatory subunit alpha | protein | 266 | 64% helix, 11% strand | P27986 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1043 | 0.87 | 0.88 | 107 | empty |
| 2 | 1053 | 0.85 | 0.85 | 88 | empty |
| 3 | 353 | 0.71 | 0.83 | 39 | empty |
| 4 | 281 | 0.67 | 0.82 | 31 | empty |
| 5 | 353 | 0.66 | 0.81 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 3219 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- P42336 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42336
- Every structure of UniProt P27986
- Elsewhere: RCSB PDB 8TS7 · PDBe 8TS7 · UniProt P42336 · UniProt P27986
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