MolNFT v2 · #220572 · protein
Transporter associated with antigen processing (TAP) bound to the 14-mer peptide LPAVVGLSPGEQEY
8T4J · Antigen peptide transporter 2: “Transporter associated with antigen processing (TAP) bound to the 14-mer peptide LPAVVGLSPGEQEY”. Electron microscopy at 3.9, 14 pockets (best druggability 0.84). MolNFT v2 #220572 on GenesisL1: 3D…
- PDB
- 8T4J
- Type
- protein
- Length
- 1,107 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.9
- Source
- Homo sapiens; SYNTHETIC CONSTRUCT
- Molecule
- Antigen peptide transporter 2; Antigen peptide transporter 1; HLA-B35 specific peptide
- UniProt
- Q03519, Q03518
- Pockets
- 14 · best druggability 0.84
Structure
electron microscopy · resolution 3.9 · 3 distinct chains · 65% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Antigen peptide transporter 2 | protein | 547 | 66% helix, 10% strand | Q03519 |
| A | Antigen peptide transporter 1 | protein | 552 | 66% helix, 10% strand | Q03518 |
| C | HLA-B35 specific peptide | protein | 8 | 0% helix, 0% strand | — |
Pockets
14 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1190 | 0.84 | 0.85 | 140 | empty |
| 2 | 516 | 0.79 | 0.86 | 47 | empty |
| 3 | 467 | 0.77 | 0.85 | 50 | empty |
| 4 | 567 | 0.73 | 0.81 | 55 | empty |
| 5 | 358 | 0.73 | 0.84 | 37 | empty |
Interfaces
3 interfaces between chains.
- B–A · 4691 Ų buried · 20 hydrogen bonds · protein-protein
- B–C · 436 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 278 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- Q03519 · AlphaFold monomer V2.0 prediction for antigen peptide transporter 2 (Q03519) · a predicted model of the same protein · chain B against A, TM-score 0.93
- Q03518 · AlphaFold monomer V2.0 prediction for antigen peptide transporter 1 (Q03518) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03519
- Every structure of UniProt Q03518
- Elsewhere: RCSB PDB 8T4J · PDBe 8T4J · UniProt Q03519 · UniProt Q03518
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